Expanding the scope of plant genome engineering with Cas12a orthologs and highly multiplexable editing systems

CRISPR-Cas12a is a promising genome editing system for targeting AT-rich genomic regions. Comprehensive genome engineering requires simultaneous targeting of multiple genes at defined locations. Here, to expand the targeting scope of Cas12a, we screen nine Cas12a orthologs that have not been demonst...

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Detalles Bibliográficos
Autores principales: Zhang, Yingxiao, Ren, Qiurong, Tang, Xu, Liu, Shishi, Malzahn, Aimee A., Zhou, Jianping, Wang, Jiaheng, Yin, Desuo, Pan, Changtian, Yuan, Mingzhu, Huang, Lan, Yang, Han, Zhao, Yuxin, Fang, Qing, Zheng, Xuelian, Tian, Li, Cheng, Yanhao, Le, Ysa, McCoy, Bailey, Franklin, Lidiya, Selengut, Jeremy D., Mount, Stephen M., Que, Qiudeng, Zhang, Yong, Qi, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007695/
https://www.ncbi.nlm.nih.gov/pubmed/33782402
http://dx.doi.org/10.1038/s41467-021-22330-w

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