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Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota
Exercise therapy including endurance training and resistance training is a promising non-pharmacological therapy in patients with multiple sclerosis (MS). Recent studies have revealed that exercise exerts beneficial impacts on gut microbiota. However, the role of gut microbiota in the immune benefit...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007788/ https://www.ncbi.nlm.nih.gov/pubmed/33796102 http://dx.doi.org/10.3389/fimmu.2021.628629 |
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author | Chen, Hao Shen, Liping Liu, Yingying Ma, Xiaomeng Long, Ling Ma, Xueying Ma, Lili Chen, Zhaoyu Lin, Xiuli Si, Lei Chen, Xiaohong |
author_facet | Chen, Hao Shen, Liping Liu, Yingying Ma, Xiaomeng Long, Ling Ma, Xueying Ma, Lili Chen, Zhaoyu Lin, Xiuli Si, Lei Chen, Xiaohong |
author_sort | Chen, Hao |
collection | PubMed |
description | Exercise therapy including endurance training and resistance training is a promising non-pharmacological therapy in patients with multiple sclerosis (MS). Recent studies have revealed that exercise exerts beneficial impacts on gut microbiota. However, the role of gut microbiota in the immune benefits of strength exercise (SE; one of resistance training) in central nervous system (CNS) autoimmunity is barely known. Here, we observed that 60-min SE ameliorated disease severity and neuropathology in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. SE increased the abundance and diversity of the gut microbiota, and decreased Firmicutes/Bacteroidetes ratio (F/B ratio) and intestinal mucosal permeability, and enrichment of several short-chain fatty acid (SCFA)-producing bacteria. Furthermore, SE reduced Th17 responses and increased Treg responses in the small intestine lymphoid tissues. Compared to the control group, microbiota-depleted mice receiving SE microbiome fecal transplants had lower disease severity and neuropathology scores. These results uncovered a protective role of SE in neuroimmunomodulation effects partly via changes to the gut microbiome. |
format | Online Article Text |
id | pubmed-8007788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80077882021-03-31 Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota Chen, Hao Shen, Liping Liu, Yingying Ma, Xiaomeng Long, Ling Ma, Xueying Ma, Lili Chen, Zhaoyu Lin, Xiuli Si, Lei Chen, Xiaohong Front Immunol Immunology Exercise therapy including endurance training and resistance training is a promising non-pharmacological therapy in patients with multiple sclerosis (MS). Recent studies have revealed that exercise exerts beneficial impacts on gut microbiota. However, the role of gut microbiota in the immune benefits of strength exercise (SE; one of resistance training) in central nervous system (CNS) autoimmunity is barely known. Here, we observed that 60-min SE ameliorated disease severity and neuropathology in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. SE increased the abundance and diversity of the gut microbiota, and decreased Firmicutes/Bacteroidetes ratio (F/B ratio) and intestinal mucosal permeability, and enrichment of several short-chain fatty acid (SCFA)-producing bacteria. Furthermore, SE reduced Th17 responses and increased Treg responses in the small intestine lymphoid tissues. Compared to the control group, microbiota-depleted mice receiving SE microbiome fecal transplants had lower disease severity and neuropathology scores. These results uncovered a protective role of SE in neuroimmunomodulation effects partly via changes to the gut microbiome. Frontiers Media S.A. 2021-03-16 /pmc/articles/PMC8007788/ /pubmed/33796102 http://dx.doi.org/10.3389/fimmu.2021.628629 Text en Copyright © 2021 Chen, Shen, Liu, Ma, Long, Ma, Ma, Chen, Lin, Si and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Chen, Hao Shen, Liping Liu, Yingying Ma, Xiaomeng Long, Ling Ma, Xueying Ma, Lili Chen, Zhaoyu Lin, Xiuli Si, Lei Chen, Xiaohong Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota |
title | Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota |
title_full | Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota |
title_fullStr | Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota |
title_full_unstemmed | Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota |
title_short | Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota |
title_sort | strength exercise confers protection in central nervous system autoimmunity by altering the gut microbiota |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007788/ https://www.ncbi.nlm.nih.gov/pubmed/33796102 http://dx.doi.org/10.3389/fimmu.2021.628629 |
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