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Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction

DNA damage activates cell cycle checkpoint proteins ATR and CHK1 to arrest cell cycle progression, providing time for repair and recovery. Consequently, inhibitors of ATR (ATRi) and CHK1 (CHK1i) enhance damage-induced cell death. Intriguingly, both CHK1i and ATRi alone elicit cytotoxicity in some ce...

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Detalles Bibliográficos
Autores principales:	Ditano, Jennifer P., Donahue, Katelyn L., Tafe, Laura J., McCleery, Charlotte F., Eastman, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007816/ https://www.ncbi.nlm.nih.gov/pubmed/33782497 http://dx.doi.org/10.1038/s41598-021-86490-x

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