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Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation

Human immunodeficiency virus-1 (HIV-1), the causative agent of AIDS, impacts millions of people. Entry into target cells is mediated by the HIV-1 envelope (Env) glycoprotein interacting with host receptor CD4, which triggers conformational changes allowing binding to a coreceptor and subsequent memb...

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Detalles Bibliográficos
Autores principales:	Jette, Claudia A., Barnes, Christopher O., Kirk, Sharon M., Melillo, Bruno, Smith, Amos B., Bjorkman, Pamela J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007822/ https://www.ncbi.nlm.nih.gov/pubmed/33782388 http://dx.doi.org/10.1038/s41467-021-21816-x

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