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Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases

BACKGROUND: Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial...

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Autores principales: Starzer, Angelika M., Steindl, Ariane, Mair, Maximilian J., Deischinger, Carola, Simonovska, Anika, Widhalm, Georg, Gatterbauer, Brigitte, Dieckmann, Karin, Heller, Gerwin, Preusser, Matthias, Berghoff, Anna S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007827/
https://www.ncbi.nlm.nih.gov/pubmed/33473170
http://dx.doi.org/10.1038/s41416-020-01254-0
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author Starzer, Angelika M.
Steindl, Ariane
Mair, Maximilian J.
Deischinger, Carola
Simonovska, Anika
Widhalm, Georg
Gatterbauer, Brigitte
Dieckmann, Karin
Heller, Gerwin
Preusser, Matthias
Berghoff, Anna S.
author_facet Starzer, Angelika M.
Steindl, Ariane
Mair, Maximilian J.
Deischinger, Carola
Simonovska, Anika
Widhalm, Georg
Gatterbauer, Brigitte
Dieckmann, Karin
Heller, Gerwin
Preusser, Matthias
Berghoff, Anna S.
author_sort Starzer, Angelika M.
collection PubMed
description BACKGROUND: Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHODS: One thousand two hundred and fifty patients with newly diagnosed brain metastases (BM) were identified from the Vienna Brain Metastasis Registry. RESULTS: PLR and CRP/Alb were higher in patients with progressive extracranial disease and lower in patients with no evidence of extracranial disease. Lower NLR (cut-off = 5.07; 9.3 vs. 5.0 months), LLR (cut-off = 5.76; 10.0 vs. 5.3 months), PLR (cut-off = 335; 8.0 vs. 3.8 months), MLR (cut-off = 0.53; 6.0 vs. 3.5 months) and CRP/Alb (cut-off = 2.93; 8.5 vs. 3.7 months; p(adj) < 0.05) were associated with longer overall survival (OS). In multivariate analysis with graded prognostic assessment (hazard ratio (HR) 1.45; 95% confidence interval (CI): 1.32–1.59; p(adj) = 1.62e − 13()), NLR (HR 1.55; 95% CI: 1.38–1.75; p(adj) = 1.92e − 11), LLR (HR 1.57; 95% CI: 1.39–1.77; p(adj) = 1.96e − 11()), PLR (HR 1.60; 95% CI: 1.39–1.85; p(adj) = 2.87955e − 9), MLR (HR 1.41; 95% CI: 1.14–1.75; p(adj) = 0.027) and CRP/Alb (HR 1.83; 95% CI: 1.54–2.18; p(adj) = 2.73e − 10) remained independent factors associated with OS at BM diagnosis. CONCLUSIONS: Systemic inflammation, measured by NLR, LLR, PLR, MLR and CRP/Alb, was associated with OS in patients with BM. Further exploration of immune modulating therapies is warranted in the setting of BM.
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spelling pubmed-80078272022-01-21 Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases Starzer, Angelika M. Steindl, Ariane Mair, Maximilian J. Deischinger, Carola Simonovska, Anika Widhalm, Georg Gatterbauer, Brigitte Dieckmann, Karin Heller, Gerwin Preusser, Matthias Berghoff, Anna S. Br J Cancer Article BACKGROUND: Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHODS: One thousand two hundred and fifty patients with newly diagnosed brain metastases (BM) were identified from the Vienna Brain Metastasis Registry. RESULTS: PLR and CRP/Alb were higher in patients with progressive extracranial disease and lower in patients with no evidence of extracranial disease. Lower NLR (cut-off = 5.07; 9.3 vs. 5.0 months), LLR (cut-off = 5.76; 10.0 vs. 5.3 months), PLR (cut-off = 335; 8.0 vs. 3.8 months), MLR (cut-off = 0.53; 6.0 vs. 3.5 months) and CRP/Alb (cut-off = 2.93; 8.5 vs. 3.7 months; p(adj) < 0.05) were associated with longer overall survival (OS). In multivariate analysis with graded prognostic assessment (hazard ratio (HR) 1.45; 95% confidence interval (CI): 1.32–1.59; p(adj) = 1.62e − 13()), NLR (HR 1.55; 95% CI: 1.38–1.75; p(adj) = 1.92e − 11), LLR (HR 1.57; 95% CI: 1.39–1.77; p(adj) = 1.96e − 11()), PLR (HR 1.60; 95% CI: 1.39–1.85; p(adj) = 2.87955e − 9), MLR (HR 1.41; 95% CI: 1.14–1.75; p(adj) = 0.027) and CRP/Alb (HR 1.83; 95% CI: 1.54–2.18; p(adj) = 2.73e − 10) remained independent factors associated with OS at BM diagnosis. CONCLUSIONS: Systemic inflammation, measured by NLR, LLR, PLR, MLR and CRP/Alb, was associated with OS in patients with BM. Further exploration of immune modulating therapies is warranted in the setting of BM. Nature Publishing Group UK 2021-01-21 2021-03-30 /pmc/articles/PMC8007827/ /pubmed/33473170 http://dx.doi.org/10.1038/s41416-020-01254-0 Text en © The Author(s), under exclusive licence to The Author(s), under exclusive licence to Cancer Research UK 2021 https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Starzer, Angelika M.
Steindl, Ariane
Mair, Maximilian J.
Deischinger, Carola
Simonovska, Anika
Widhalm, Georg
Gatterbauer, Brigitte
Dieckmann, Karin
Heller, Gerwin
Preusser, Matthias
Berghoff, Anna S.
Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases
title Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases
title_full Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases
title_fullStr Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases
title_full_unstemmed Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases
title_short Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases
title_sort systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007827/
https://www.ncbi.nlm.nih.gov/pubmed/33473170
http://dx.doi.org/10.1038/s41416-020-01254-0
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