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Blocking DNA Damage Repair May Be Involved in Stattic (STAT3 Inhibitor)-Induced FLT3-ITD AML Cell Apoptosis

The FMS-like tyrosine kinase 3 (FLT3)- internal tandem duplication (ITD) mutation can be found in approximately 25% of all acute myeloid leukemia (AML) cases and is associated with a poor prognosis. The main treatment for FLT3-ITD-positive AML patients includes genotoxic therapy and FLT3 inhibitors,...

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Detalles Bibliográficos
Autores principales:	Luo, Yuxuan, Lu, Ying, Long, Bing, Lin, Yansi, Yang, Yanling, Xu, Yichuang, Zhang, Xiangzhong, Zhang, Jingwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007876/ https://www.ncbi.nlm.nih.gov/pubmed/33796529 http://dx.doi.org/10.3389/fcell.2021.637064

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