Cargando…
Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patie...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007896/ https://www.ncbi.nlm.nih.gov/pubmed/33815703 http://dx.doi.org/10.34172/jcvtr.2021.18 |
_version_ | 1783672585555279872 |
---|---|
author | Khadivi Heris, Hengameh Nejati, Babak Rezazadeh, Khatereh Sate, Hossein Dolatkhah, Roya Ghoreishi, Zohreh Esfahani, Ali |
author_facet | Khadivi Heris, Hengameh Nejati, Babak Rezazadeh, Khatereh Sate, Hossein Dolatkhah, Roya Ghoreishi, Zohreh Esfahani, Ali |
author_sort | Khadivi Heris, Hengameh |
collection | PubMed |
description | Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patients with beta-thalassemia major who were all transfusion dependent were evaluated for the study. T2* MRI of heart and liver, echocardiography, serum ferritin level, and liver enzymes measurement were performed. The relationship between T2* MRI findings and other assessments were examined. Cardiac and hepatic T2* findings were categorized as normal, mild, moderate, and severe iron overload. Results: 22% and 11% of the patients were suffering from severe iron overload in heart and liver, respectively. The echocardiographic findings were not significantly different among different iron load categories in heart or liver. ALT level was significantly higher in patient with severe iron overload than those with normal iron load in heart (P =0.005). Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P <0.05). The serum ferritin level was significantly inversely correlated with cardiac T2* values (r = -0.34, P =0.035) and hepatic T2* values (r = -0.52, P =0.001). Conclusion: Cardiac and hepatic T2* MRI indicated significant correlation with serum ferritin level. |
format | Online Article Text |
id | pubmed-8007896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-80078962021-04-02 Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes Khadivi Heris, Hengameh Nejati, Babak Rezazadeh, Khatereh Sate, Hossein Dolatkhah, Roya Ghoreishi, Zohreh Esfahani, Ali J Cardiovasc Thorac Res Original Article Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patients with beta-thalassemia major who were all transfusion dependent were evaluated for the study. T2* MRI of heart and liver, echocardiography, serum ferritin level, and liver enzymes measurement were performed. The relationship between T2* MRI findings and other assessments were examined. Cardiac and hepatic T2* findings were categorized as normal, mild, moderate, and severe iron overload. Results: 22% and 11% of the patients were suffering from severe iron overload in heart and liver, respectively. The echocardiographic findings were not significantly different among different iron load categories in heart or liver. ALT level was significantly higher in patient with severe iron overload than those with normal iron load in heart (P =0.005). Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P <0.05). The serum ferritin level was significantly inversely correlated with cardiac T2* values (r = -0.34, P =0.035) and hepatic T2* values (r = -0.52, P =0.001). Conclusion: Cardiac and hepatic T2* MRI indicated significant correlation with serum ferritin level. Tabriz University of Medical Sciences 2021 2021-02-18 /pmc/articles/PMC8007896/ /pubmed/33815703 http://dx.doi.org/10.34172/jcvtr.2021.18 Text en © 2021 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khadivi Heris, Hengameh Nejati, Babak Rezazadeh, Khatereh Sate, Hossein Dolatkhah, Roya Ghoreishi, Zohreh Esfahani, Ali Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes |
title | Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes |
title_full | Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes |
title_fullStr | Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes |
title_full_unstemmed | Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes |
title_short | Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes |
title_sort | evaluation of iron overload by cardiac and liver t2* in β-thalassemia: correlation with serum ferritin, heart function and liver enzymes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007896/ https://www.ncbi.nlm.nih.gov/pubmed/33815703 http://dx.doi.org/10.34172/jcvtr.2021.18 |
work_keys_str_mv | AT khadiviherishengameh evaluationofironoverloadbycardiacandlivert2inbthalassemiacorrelationwithserumferritinheartfunctionandliverenzymes AT nejatibabak evaluationofironoverloadbycardiacandlivert2inbthalassemiacorrelationwithserumferritinheartfunctionandliverenzymes AT rezazadehkhatereh evaluationofironoverloadbycardiacandlivert2inbthalassemiacorrelationwithserumferritinheartfunctionandliverenzymes AT satehossein evaluationofironoverloadbycardiacandlivert2inbthalassemiacorrelationwithserumferritinheartfunctionandliverenzymes AT dolatkhahroya evaluationofironoverloadbycardiacandlivert2inbthalassemiacorrelationwithserumferritinheartfunctionandliverenzymes AT ghoreishizohreh evaluationofironoverloadbycardiacandlivert2inbthalassemiacorrelationwithserumferritinheartfunctionandliverenzymes AT esfahaniali evaluationofironoverloadbycardiacandlivert2inbthalassemiacorrelationwithserumferritinheartfunctionandliverenzymes |