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Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes

Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patie...

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Autores principales: Khadivi Heris, Hengameh, Nejati, Babak, Rezazadeh, Khatereh, Sate, Hossein, Dolatkhah, Roya, Ghoreishi, Zohreh, Esfahani, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007896/
https://www.ncbi.nlm.nih.gov/pubmed/33815703
http://dx.doi.org/10.34172/jcvtr.2021.18
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author Khadivi Heris, Hengameh
Nejati, Babak
Rezazadeh, Khatereh
Sate, Hossein
Dolatkhah, Roya
Ghoreishi, Zohreh
Esfahani, Ali
author_facet Khadivi Heris, Hengameh
Nejati, Babak
Rezazadeh, Khatereh
Sate, Hossein
Dolatkhah, Roya
Ghoreishi, Zohreh
Esfahani, Ali
author_sort Khadivi Heris, Hengameh
collection PubMed
description Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patients with beta-thalassemia major who were all transfusion dependent were evaluated for the study. T2* MRI of heart and liver, echocardiography, serum ferritin level, and liver enzymes measurement were performed. The relationship between T2* MRI findings and other assessments were examined. Cardiac and hepatic T2* findings were categorized as normal, mild, moderate, and severe iron overload. Results: 22% and 11% of the patients were suffering from severe iron overload in heart and liver, respectively. The echocardiographic findings were not significantly different among different iron load categories in heart or liver. ALT level was significantly higher in patient with severe iron overload than those with normal iron load in heart (P =0.005). Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P <0.05). The serum ferritin level was significantly inversely correlated with cardiac T2* values (r = -0.34, P =0.035) and hepatic T2* values (r = -0.52, P =0.001). Conclusion: Cardiac and hepatic T2* MRI indicated significant correlation with serum ferritin level.
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spelling pubmed-80078962021-04-02 Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes Khadivi Heris, Hengameh Nejati, Babak Rezazadeh, Khatereh Sate, Hossein Dolatkhah, Roya Ghoreishi, Zohreh Esfahani, Ali J Cardiovasc Thorac Res Original Article Introduction: In this study, we aimed to assess the relationship of cardiac and hepatic T2* magnetic resonance imaging (MRI) values as a gold standard for detecting iron overload with serum ferritin level, heart function, and liver enzymes as alternative diagnostic methods. Methods: A total 58 patients with beta-thalassemia major who were all transfusion dependent were evaluated for the study. T2* MRI of heart and liver, echocardiography, serum ferritin level, and liver enzymes measurement were performed. The relationship between T2* MRI findings and other assessments were examined. Cardiac and hepatic T2* findings were categorized as normal, mild, moderate, and severe iron overload. Results: 22% and 11% of the patients were suffering from severe iron overload in heart and liver, respectively. The echocardiographic findings were not significantly different among different iron load categories in heart or liver. ALT level was significantly higher in patient with severe iron overload than those with normal iron load in heart (P =0.005). Also, AST level was significantly lower in normal iron load group than mild, moderate, and severe iron load groups in liver (P <0.05). The serum ferritin level was significantly inversely correlated with cardiac T2* values (r = -0.34, P =0.035) and hepatic T2* values (r = -0.52, P =0.001). Conclusion: Cardiac and hepatic T2* MRI indicated significant correlation with serum ferritin level. Tabriz University of Medical Sciences 2021 2021-02-18 /pmc/articles/PMC8007896/ /pubmed/33815703 http://dx.doi.org/10.34172/jcvtr.2021.18 Text en © 2021 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khadivi Heris, Hengameh
Nejati, Babak
Rezazadeh, Khatereh
Sate, Hossein
Dolatkhah, Roya
Ghoreishi, Zohreh
Esfahani, Ali
Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
title Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
title_full Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
title_fullStr Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
title_full_unstemmed Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
title_short Evaluation of iron overload by cardiac and liver T2* in β-thalassemia: Correlation with serum ferritin, heart function and liver enzymes
title_sort evaluation of iron overload by cardiac and liver t2* in β-thalassemia: correlation with serum ferritin, heart function and liver enzymes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007896/
https://www.ncbi.nlm.nih.gov/pubmed/33815703
http://dx.doi.org/10.34172/jcvtr.2021.18
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