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Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study

Introduction: Vascular access thrombosis increases the risk of mortality and morbidity in end-stage renal disease (ESRD) patients on hemodialysis (HD). This study aimed to evaluate hereditary thrombophilia factors in HD patients and its association with tunneled cuffed catheters’ thrombosis. Methods...

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Autores principales: Kakaei, Farzad, Mirabolfathi, Saba, Yavari, Negin, Ardalan, Mohammad Reza, Mozafar, Mehrdad, Zarrintan, Sina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007903/
https://www.ncbi.nlm.nih.gov/pubmed/33815706
http://dx.doi.org/10.34172/jcvtr.2021.06
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author Kakaei, Farzad
Mirabolfathi, Saba
Yavari, Negin
Ardalan, Mohammad Reza
Mozafar, Mehrdad
Zarrintan, Sina
author_facet Kakaei, Farzad
Mirabolfathi, Saba
Yavari, Negin
Ardalan, Mohammad Reza
Mozafar, Mehrdad
Zarrintan, Sina
author_sort Kakaei, Farzad
collection PubMed
description Introduction: Vascular access thrombosis increases the risk of mortality and morbidity in end-stage renal disease (ESRD) patients on hemodialysis (HD). This study aimed to evaluate hereditary thrombophilia factors in HD patients and its association with tunneled cuffed catheters’ thrombosis. Methods: In this cross-sectional study, 60 consecutive patients with ESRD on HD with tunneled cuffed catheters were selected. Inherited thrombophilia factors (Anti-thrombin III, Protein C, Protein S, and Factor V Leiden) were measured and the patients were followed for 3 months to evaluate the incidence of catheter-related thrombosis. The association between these factors and catheter thrombosis was assessed. Results: The mean age of patients was 60.30 ± 8.69 years. Forty-seven patients (78.30%) were female and thirteen patients (21.70%) were male. The most common cause of ESRD was diabetes mellitus (41.67%). The most catheter site was the right internal jugular vein (55%). There were 22 (36.67%) and 8 (13.33%) cases of thrombosis and mortality, respectively. The association between hereditary thrombophilia factors and catheter thrombosis was not statistically significant (P > 0.05). Conclusion: In this small group of our patients, the frequency of hereditary thrombophilia was not significantly different between those with and without thrombosis of tunneled HD catheter.
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spelling pubmed-80079032021-04-02 Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study Kakaei, Farzad Mirabolfathi, Saba Yavari, Negin Ardalan, Mohammad Reza Mozafar, Mehrdad Zarrintan, Sina J Cardiovasc Thorac Res Short Communication Introduction: Vascular access thrombosis increases the risk of mortality and morbidity in end-stage renal disease (ESRD) patients on hemodialysis (HD). This study aimed to evaluate hereditary thrombophilia factors in HD patients and its association with tunneled cuffed catheters’ thrombosis. Methods: In this cross-sectional study, 60 consecutive patients with ESRD on HD with tunneled cuffed catheters were selected. Inherited thrombophilia factors (Anti-thrombin III, Protein C, Protein S, and Factor V Leiden) were measured and the patients were followed for 3 months to evaluate the incidence of catheter-related thrombosis. The association between these factors and catheter thrombosis was assessed. Results: The mean age of patients was 60.30 ± 8.69 years. Forty-seven patients (78.30%) were female and thirteen patients (21.70%) were male. The most common cause of ESRD was diabetes mellitus (41.67%). The most catheter site was the right internal jugular vein (55%). There were 22 (36.67%) and 8 (13.33%) cases of thrombosis and mortality, respectively. The association between hereditary thrombophilia factors and catheter thrombosis was not statistically significant (P > 0.05). Conclusion: In this small group of our patients, the frequency of hereditary thrombophilia was not significantly different between those with and without thrombosis of tunneled HD catheter. Tabriz University of Medical Sciences 2021 2021-01-19 /pmc/articles/PMC8007903/ /pubmed/33815706 http://dx.doi.org/10.34172/jcvtr.2021.06 Text en © 2021 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Kakaei, Farzad
Mirabolfathi, Saba
Yavari, Negin
Ardalan, Mohammad Reza
Mozafar, Mehrdad
Zarrintan, Sina
Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study
title Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study
title_full Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study
title_fullStr Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study
title_full_unstemmed Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study
title_short Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study
title_sort hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: a single center study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007903/
https://www.ncbi.nlm.nih.gov/pubmed/33815706
http://dx.doi.org/10.34172/jcvtr.2021.06
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