Tumor Hypoxia Drives Genomic Instability

Cancer is a leading cause of death worldwide. As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance. The enhanced tumor aggressiveness stems at least partially from hypoxia-induced genomic instability. Therefore, a...

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Detalles Bibliográficos
Autores principales: Tang, Ming, Bolderson, Emma, O’Byrne, Kenneth J., Richard, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007910/
https://www.ncbi.nlm.nih.gov/pubmed/33796526
http://dx.doi.org/10.3389/fcell.2021.626229
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author Tang, Ming
Bolderson, Emma
O’Byrne, Kenneth J.
Richard, Derek J.
author_facet Tang, Ming
Bolderson, Emma
O’Byrne, Kenneth J.
Richard, Derek J.
author_sort Tang, Ming
collection PubMed
description Cancer is a leading cause of death worldwide. As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance. The enhanced tumor aggressiveness stems at least partially from hypoxia-induced genomic instability. Therefore, a clear understanding of how tumor hypoxia induces genomic instability is crucial for the improvement of cancer therapeutics. This review summarizes recent developments highlighting the association of tumor hypoxia with genomic instability and the mechanisms by which tumor hypoxia drives genomic instability, followed by how hypoxic tumors can be specifically targeted to maximize efficacy.
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spelling pubmed-80079102021-03-31 Tumor Hypoxia Drives Genomic Instability Tang, Ming Bolderson, Emma O’Byrne, Kenneth J. Richard, Derek J. Front Cell Dev Biol Cell and Developmental Biology Cancer is a leading cause of death worldwide. As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance. The enhanced tumor aggressiveness stems at least partially from hypoxia-induced genomic instability. Therefore, a clear understanding of how tumor hypoxia induces genomic instability is crucial for the improvement of cancer therapeutics. This review summarizes recent developments highlighting the association of tumor hypoxia with genomic instability and the mechanisms by which tumor hypoxia drives genomic instability, followed by how hypoxic tumors can be specifically targeted to maximize efficacy. Frontiers Media S.A. 2021-03-16 /pmc/articles/PMC8007910/ /pubmed/33796526 http://dx.doi.org/10.3389/fcell.2021.626229 Text en Copyright © 2021 Tang, Bolderson, O’Byrne and Richard. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Tang, Ming
Bolderson, Emma
O’Byrne, Kenneth J.
Richard, Derek J.
Tumor Hypoxia Drives Genomic Instability
title Tumor Hypoxia Drives Genomic Instability
title_full Tumor Hypoxia Drives Genomic Instability
title_fullStr Tumor Hypoxia Drives Genomic Instability
title_full_unstemmed Tumor Hypoxia Drives Genomic Instability
title_short Tumor Hypoxia Drives Genomic Instability
title_sort tumor hypoxia drives genomic instability
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007910/
https://www.ncbi.nlm.nih.gov/pubmed/33796526
http://dx.doi.org/10.3389/fcell.2021.626229
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