Cargando…

The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy

Mesenchymal stromal cells (MSCs) currently constitute the most frequently used cell type in advanced therapies with different purposes, most of which are related with inflammatory processes. Although the therapeutic efficacy of these cells has been clearly demonstrated in different disease animal mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	García-Bernal, David, García-Arranz, Mariano, Yáñez, Rosa M., Hervás-Salcedo, Rosario, Cortés, Alfonso, Fernández-García, María, Hernando-Rodríguez, Miriam, Quintana-Bustamante, Óscar, Bueren, Juan A., García-Olmo, Damián, Moraleda, Jose M., Segovia, José C., Zapata, Agustín G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007911/ https://www.ncbi.nlm.nih.gov/pubmed/33796536 http://dx.doi.org/10.3389/fcell.2021.650664

Ejemplares similares

Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10
por: Hervás-Salcedo, Rosario, et al.
Publicado: (2021)

Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile
por: García-Bernal, David, et al.
Publicado: (2020)

Improved efficacy of mesenchymal stromal cells stably expressing CXCR4 and IL-10 in a xenogeneic graft versus host disease mouse model
por: Hervás-Salcedo, Rosario, et al.
Publicado: (2023)

Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome
por: Fernández-Santos, Maria Eugenia, et al.
Publicado: (2022)

Aquaporin water channels: unanswered questions and unresolved controversies
por: Agre, Peter, et al.
Publicado: (1995)

Development and Characterization of a Factor V-Deficient CRISPR Cell Model for the Correction of Mutations
por: Serrano, Luis Javier, et al.
Publicado: (2022)

Preliminary study on non-viral transfection of F9 (factor IX) gene by nucleofection in human adipose-derived mesenchymal stem cells
por: Olmedillas López, Susana, et al.
Publicado: (2016)

Stem cell therapy for faecal incontinence: Current state and future perspectives
por: Trébol, Jacobo, et al.
Publicado: (2018)

New method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing
por: Rubio-Mangas, David, et al.
Publicado: (2023)

KRAS G12V Mutation Detection by Droplet Digital PCR in Circulating Cell-Free DNA of Colorectal Cancer Patients
por: Olmedillas López, Susana, et al.
Publicado: (2016)

Unresolved issues and controversies surrounding the management of colorectal cancer liver metastasis
por: Kassahun, Woubet T
Publicado: (2015)

Parafalcine subdural empyema: The unresolved controversy over the need for surgical treatment
por: Prieto, Ruth, et al.
Publicado: (2019)

Liquid biopsy by NGS: differential presence of exons (DPE) in cell‐free DNA reveals different patterns in metastatic and nonmetastatic colorectal cancer
por: Olmedillas‐López, Susana, et al.
Publicado: (2018)

COVID-19: Some unresolved issues
por: Gómez-Pavón, Javier, et al.
Publicado: (2022)

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice
por: Fañanas-Baquero, Sara, et al.
Publicado: (2020)

Cell Therapy With Mesenchymal Stem Cells Induces an Innate Immune Memory Response That Attenuates Experimental Colitis in the Long Term
por: Lopez-Santalla, Mercedes, et al.
Publicado: (2020)

Defining “FGF21 Resistance” during obesity: Controversy, criteria and unresolved questions
por: Markan, Kathleen R.
Publicado: (2018)

Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review
por: Georgiev-Hristov, Tihomir, et al.
Publicado: (2022)

Liquid biopsy by NGS: Differential presence of exons (DPE) is related to metastatic potential in a colon-cancer model in the rat
por: García-Olmo, Dolores C., et al.
Publicado: (2020)

The role of mucin cell-free DNA detection as a new marker for the study of acellular pseudomyxoma peritonei of appendicular origin by liquid biopsy
por: García-Olmo, Damián, et al.
Publicado: (2020)

The effects of allogenic stem cells in a murine model of hind limb diabetic ischemic tissue
por: Álvarez García, Jesús, et al.
Publicado: (2017)

Stem cell therapy applied for digestive anastomosis: Current state and future perspectives
por: Trébol, Jacobo, et al.
Publicado: (2022)

Analysis of Septin 9 Gene Hypermethylation as Follow-Up Biomarker of Colorectal Cancer Patients after Curative Surgery
por: Leon Arellano, Miguel, et al.
Publicado: (2022)

Differential presence of exons (DPE): sequencing liquid biopsy by NGS. A new method for clustering colorectal Cancer patients
por: Rubio-Mangas, David, et al.
Publicado: (2023)

Main histological parameters to be evaluated in an experimental model of myocardial infarct treated by stem cells on pigs
por: García Gómez-Heras, Soledad, et al.
Publicado: (2019)

Rat model of anal sphincter injury and two approaches for stem cell administration
por: Trébol, Jacobo, et al.
Publicado: (2018)

Liquid biopsy in peritoneal fluid and plasma as a prognostic factor in advanced colorectal and appendiceal tumors after complete cytoreduction and hyperthermic intraperitoneal chemotherapy
por: López-Rojo, Irene, et al.
Publicado: (2020)

Autologous adipose‐derived stem cells for the treatment of complex cryptoglandular perianal fistula: A randomized clinical trial with long‐term follow‐up
por: Garcia‐Arranz, Mariano, et al.
Publicado: (2019)

Facts of Vertigo in Adolescents: Controversies and Challenges – A Narrative Review
por: Castillo-Bustamante, Melissa, et al.
Publicado: (2022)

Are Controversial Issues in Cervical Total Disc Replacement Resolved or Unresolved?: A Review of Literature and Recent Updates
por: Park, Chun-Kun, et al.
Publicado: (2018)

Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model
por: Fernández-García, María, et al.
Publicado: (2015)

Preterm birth, an unresolved issue
por: Belizán, Jose M, et al.
Publicado: (2013)

Surgical Options for Optic Disc Pit Maculopathy: Perspectives and Controversies
por: Pastor-Idoate, Salvador, et al.
Publicado: (2020)

Two phase I/II clinical trials for the treatment of urinary incontinence with autologous mesenchymal stem cells
por: Garcia‐Arranz, Mariano, et al.
Publicado: (2020)

Chemical Scalpel: An Experimental Collagenase-Based Treatment for Peritoneal Adhesions
por: Barambio, Javier, et al.
Publicado: (2022)

Controversies in the Management of the First Time Shoulder Dislocation
por: Avila Lafuente, José Luis, et al.
Publicado: (2017)

Circulating nucleic acids in plasma and serum (CNAPS): applications in oncology
por: González-Masiá, José A, et al.
Publicado: (2013)

Oncological transformation in vitro of hepatic progenitor cell lines isolated from adult mice
por: Olivera-Salazar, Rocío, et al.
Publicado: (2022)

Role of Hospital Exemption in Europe: position paper from the Spanish Advanced Therapy Network (TERAV)
por: Sánchez-Guijo, Fermín, et al.
Publicado: (2023)

Current Controversy: Spikes, Bursts, and Synchrony in Generalized Absence Epilepsy: Unresolved Questions Regarding Thalamocortical Synchrony in Absence Epilepsy
por: Huguenard, John
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9mklj6usogiss9ms8j604v20f9