Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression

This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, u...

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Autores principales: Okoye, Jude O., Ngokere, Anthony A., Onyenekwe, Charles C., Omotuyi, Olaposi, Dada, Deborah I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008003/
https://www.ncbi.nlm.nih.gov/pubmed/33824853
http://dx.doi.org/10.4102/ajlm.v10i1.975
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author Okoye, Jude O.
Ngokere, Anthony A.
Onyenekwe, Charles C.
Omotuyi, Olaposi
Dada, Deborah I.
author_facet Okoye, Jude O.
Ngokere, Anthony A.
Onyenekwe, Charles C.
Omotuyi, Olaposi
Dada, Deborah I.
author_sort Okoye, Jude O.
collection PubMed
description This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182.
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spelling pubmed-80080032021-04-05 Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression Okoye, Jude O. Ngokere, Anthony A. Onyenekwe, Charles C. Omotuyi, Olaposi Dada, Deborah I. Afr J Lab Med Brief Report This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182. AOSIS 2021-03-16 /pmc/articles/PMC8008003/ /pubmed/33824853 http://dx.doi.org/10.4102/ajlm.v10i1.975 Text en © 2021. The Authors https://creativecommons.org/licenses/by/4.0/ Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.
spellingShingle Brief Report
Okoye, Jude O.
Ngokere, Anthony A.
Onyenekwe, Charles C.
Omotuyi, Olaposi
Dada, Deborah I.
Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression
title Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression
title_full Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression
title_fullStr Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression
title_full_unstemmed Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression
title_short Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression
title_sort epstein-barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates mirna expression
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008003/
https://www.ncbi.nlm.nih.gov/pubmed/33824853
http://dx.doi.org/10.4102/ajlm.v10i1.975
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