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Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling

Somatic malignant transformation in a germ cell tumor (GCT) is the development of non-germ malignancies; much of available literature refers to teratoma with malignant transformation (TMT). There are various transformation histologies such as sarcoma, adenocarcinoma, primitive neuroectodermal tumors...

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Autores principales: Pantaleo, Maria A., Mandruzzato, Marcella, Indio, Valentina, Urbini, Milena, Nannini, Margherita, Gatto, Lidia, Schipani, Angela, Fiorentino, Michelangelo, Franceschini, Tania, Ambrosini, Valentina, Di Scioscio, Valerio, Saponara, Maristella, Ianni, Manuela, Concetti, Sergio, Altimari, Annalisa, Ardizzoni, Andrea, Astolfi, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008106/
https://www.ncbi.nlm.nih.gov/pubmed/33796464
http://dx.doi.org/10.3389/fonc.2021.633543
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author Pantaleo, Maria A.
Mandruzzato, Marcella
Indio, Valentina
Urbini, Milena
Nannini, Margherita
Gatto, Lidia
Schipani, Angela
Fiorentino, Michelangelo
Franceschini, Tania
Ambrosini, Valentina
Di Scioscio, Valerio
Saponara, Maristella
Ianni, Manuela
Concetti, Sergio
Altimari, Annalisa
Ardizzoni, Andrea
Astolfi, Annalisa
author_facet Pantaleo, Maria A.
Mandruzzato, Marcella
Indio, Valentina
Urbini, Milena
Nannini, Margherita
Gatto, Lidia
Schipani, Angela
Fiorentino, Michelangelo
Franceschini, Tania
Ambrosini, Valentina
Di Scioscio, Valerio
Saponara, Maristella
Ianni, Manuela
Concetti, Sergio
Altimari, Annalisa
Ardizzoni, Andrea
Astolfi, Annalisa
author_sort Pantaleo, Maria A.
collection PubMed
description Somatic malignant transformation in a germ cell tumor (GCT) is the development of non-germ malignancies; much of available literature refers to teratoma with malignant transformation (TMT). There are various transformation histologies such as sarcoma, adenocarcinoma, primitive neuroectodermal tumors, and more rarely carcinoid tumors, hemangioendothelioma, lymphoma, or nephroblastoma. The treatments of these entities include surgery and/or chemotherapy. A standard approach in choosing chemotherapy in TMT cases has not yet been established. Many authors suggest using chemotherapeutic agents based on the transformed histology, while others recommend GCT-oriented therapy combined with surgery as the primary treatment, reserving histology-driven chemotherapies for metastatic relapse. We report the clinical findings and the genomic profile of a mixed GCT case with somatic-type malignancy of sarcoma type. We achieved a complete radiological response with GCT-oriented chemotherapy performed as salvage therapy after sarcoma-histology therapy. In addition, molecular profiles with RNA-sequencing and exome sequencing analyses of the primary tumor and the tumor with somatic-type malignancy of sarcoma type were explored.
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spelling pubmed-80081062021-03-31 Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling Pantaleo, Maria A. Mandruzzato, Marcella Indio, Valentina Urbini, Milena Nannini, Margherita Gatto, Lidia Schipani, Angela Fiorentino, Michelangelo Franceschini, Tania Ambrosini, Valentina Di Scioscio, Valerio Saponara, Maristella Ianni, Manuela Concetti, Sergio Altimari, Annalisa Ardizzoni, Andrea Astolfi, Annalisa Front Oncol Oncology Somatic malignant transformation in a germ cell tumor (GCT) is the development of non-germ malignancies; much of available literature refers to teratoma with malignant transformation (TMT). There are various transformation histologies such as sarcoma, adenocarcinoma, primitive neuroectodermal tumors, and more rarely carcinoid tumors, hemangioendothelioma, lymphoma, or nephroblastoma. The treatments of these entities include surgery and/or chemotherapy. A standard approach in choosing chemotherapy in TMT cases has not yet been established. Many authors suggest using chemotherapeutic agents based on the transformed histology, while others recommend GCT-oriented therapy combined with surgery as the primary treatment, reserving histology-driven chemotherapies for metastatic relapse. We report the clinical findings and the genomic profile of a mixed GCT case with somatic-type malignancy of sarcoma type. We achieved a complete radiological response with GCT-oriented chemotherapy performed as salvage therapy after sarcoma-histology therapy. In addition, molecular profiles with RNA-sequencing and exome sequencing analyses of the primary tumor and the tumor with somatic-type malignancy of sarcoma type were explored. Frontiers Media S.A. 2021-03-16 /pmc/articles/PMC8008106/ /pubmed/33796464 http://dx.doi.org/10.3389/fonc.2021.633543 Text en Copyright © 2021 Pantaleo, Mandruzzato, Indio, Urbini, Nannini, Gatto, Schipani, Fiorentino, Franceschini, Ambrosini, Di Scioscio, Saponara, Ianni, Concetti, Altimari, Ardizzoni and Astolfi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Pantaleo, Maria A.
Mandruzzato, Marcella
Indio, Valentina
Urbini, Milena
Nannini, Margherita
Gatto, Lidia
Schipani, Angela
Fiorentino, Michelangelo
Franceschini, Tania
Ambrosini, Valentina
Di Scioscio, Valerio
Saponara, Maristella
Ianni, Manuela
Concetti, Sergio
Altimari, Annalisa
Ardizzoni, Andrea
Astolfi, Annalisa
Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling
title Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling
title_full Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling
title_fullStr Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling
title_full_unstemmed Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling
title_short Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling
title_sort case report: the complete remission of a mixed germ cell tumor with somatic type malignancy of sarcoma type with a gct-oriented therapy: clinical findings and genomic profiling
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008106/
https://www.ncbi.nlm.nih.gov/pubmed/33796464
http://dx.doi.org/10.3389/fonc.2021.633543
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