Cargando…

Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling

Somatic malignant transformation in a germ cell tumor (GCT) is the development of non-germ malignancies; much of available literature refers to teratoma with malignant transformation (TMT). There are various transformation histologies such as sarcoma, adenocarcinoma, primitive neuroectodermal tumors...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pantaleo, Maria A., Mandruzzato, Marcella, Indio, Valentina, Urbini, Milena, Nannini, Margherita, Gatto, Lidia, Schipani, Angela, Fiorentino, Michelangelo, Franceschini, Tania, Ambrosini, Valentina, Di Scioscio, Valerio, Saponara, Maristella, Ianni, Manuela, Concetti, Sergio, Altimari, Annalisa, Ardizzoni, Andrea, Astolfi, Annalisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008106/ https://www.ncbi.nlm.nih.gov/pubmed/33796464 http://dx.doi.org/10.3389/fonc.2021.633543

Ejemplares similares

(18)F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature
por: Saponara, Maristella, et al.
Publicado: (2018)

Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST
por: Astolfi, Annalisa, et al.
Publicado: (2020)

Gene Expression Landscape of SDH-Deficient Gastrointestinal Stromal Tumors
por: Indio, Valentina, et al.
Publicado: (2021)

Genetic aberrations and molecular biology of cardiac sarcoma
por: Urbini, Milena, et al.
Publicado: (2020)

Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib
por: Nannini, Margherita, et al.
Publicado: (2019)

The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor
por: Astolfi, Annalisa, et al.
Publicado: (2020)

Gain of FGF4 is a frequent event in KIT/PDGFRA/SDH/RAS‐P WT GIST
por: Urbini, Milena, et al.
Publicado: (2019)

SDHA Germline Variants in Adult Patients With SDHA-Mutant Gastrointestinal Stromal Tumor
por: Pantaleo, Maria A., et al.
Publicado: (2022)

Complete radiological response to first-line regorafenib in a patient with abdominal relapse of BRAF V600E mutated GIST
por: Nannini, Margherita, et al.
Publicado: (2020)

Targeted therapy in SDH-deficient GIST
por: Nannini, Margherita, et al.
Publicado: (2021)

Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)
por: Saponara, Maristella, et al.
Publicado: (2015)

Paratesticular Mesenchymal Malignancies: A Single-Center Case Series, Clinical Management, and Review of Literature
por: Gatto, Lidia, et al.
Publicado: (2020)

Whole exome sequencing (WES) on formalin-fixed, paraffin-embedded (FFPE) tumor tissue in gastrointestinal stromal tumors (GIST)
por: Astolfi, Annalisa, et al.
Publicado: (2015)

Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation
por: Indio, Valentina, et al.
Publicado: (2020)

Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)
por: Nannini, Margherita, et al.
Publicado: (2014)

Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene
por: Indio, Valentina, et al.
Publicado: (2018)

Dystrophin deregulation is associated with tumor progression in KIT/PDGFRA mutant gastrointestinal stromal tumors
por: Pantaleo, Maria A, et al.
Publicado: (2014)

Immune microenvironment profiling of gastrointestinal stromal tumors (GIST) shows gene expression patterns associated to immune checkpoint inhibitors response
por: Pantaleo, Maria A., et al.
Publicado: (2019)

Whole Exome Sequencing Uncovers Germline Variants of Cancer-Related Genes in Sporadic Pheochromocytoma
por: Urbini, Milena, et al.
Publicado: (2018)

Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report
por: Saponara, Maristella, et al.
Publicado: (2019)

The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)
por: Nannini, Margherita, et al.
Publicado: (2017)

SRF Rearrangements in Soft Tissue Tumors with Muscle Differentiation
por: Costa, Alice, et al.
Publicado: (2022)

The Identity of PDGFRA D842V-Mutant Gastrointestinal Stromal Tumors (GIST)
por: Rizzo, Alessandro, et al.
Publicado: (2021)

Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile
por: Astolfi, Annalisa, et al.
Publicado: (2020)

SDHC methylation in gastrointestinal stromal tumors (GIST): a case report
por: Urbini, Milena, et al.
Publicado: (2015)

Gene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST
por: Urbini, Milena, et al.
Publicado: (2020)

SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update
por: Schipani, Angela, et al.
Publicado: (2023)

Impact of Chemotherapy in the Adjuvant Setting of Early Stage Uterine Leiomyosarcoma: A Systematic Review and Updated Meta-Analysis
por: Rizzo, Alessandro, et al.
Publicado: (2020)

Personalization of regorafenib treatment in metastatic gastrointestinal stromal tumours in real-life clinical practice
por: Nannini, Margherita, et al.
Publicado: (2017)

Liquid biopsy in gastrointestinal stromal tumors: a novel approach
por: Nannini, Margherita, et al.
Publicado: (2014)

Radiotherapy in the management of gist: state of the art and new potential scenarios
por: Gatto, L., et al.
Publicado: (2017)

ADK-VR2, a cell line derived from a treatment-naïve patient with SDC4-ROS1 fusion-positive primarily crizotinib-resistant NSCLC: a novel preclinical model for new drug development of ROS1-rearranged NSCLC
por: Ruzzi, Francesca, et al.
Publicado: (2022)

Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma
por: Urbini, Milena, et al.
Publicado: (2018)

Identification of SRF-E2F1 fusion transcript in EWSR-negative myoepithelioma of the soft tissue
por: Urbini, Milena, et al.
Publicado: (2017)

Erratum to: The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)
por: Nannini, Margherita, et al.
Publicado: (2017)

Dual TMPRSS2:ERG Fusion in a Patient with Lung and Prostate Cancers
por: Giunchi, Francesca, et al.
Publicado: (2020)

Successful selective arterial embolizations for bone metastases in renal cell carcinoma integrated with systemic therapies: A case report
por: Gatto, L., et al.
Publicado: (2017)

Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets
por: Ravegnini, Gloria, et al.
Publicado: (2019)

Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
por: Lolli, Cristian, et al.
Publicado: (2011)

Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours
por: SAPONARA, MARISTELLA, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_n5mtsb2u565jnmqn0fqit174vp