Cargando…

Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study

AIM: To determine whether differences in joint and tendon stiffness as measured by ultrasound shear wave elastography are present in breast cancer patients with aromatase inhibitor-associated arthralgias compared to age-comparable healthy control women. METHODS: Postmenopausal women with stage I–III...

Descripción completa

Detalles Bibliográficos
Autores principales: Martinez, Jessica A., Taljanovic, Mihra S., Witte, Russell S., Nuncio Zuniga, Andres A., Wertheim, Betsy C., Kwoh, C. Kent, Goldstein, Brian A., Roe, Denise J., Chalasani, Pavani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Exeley Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008134/
https://www.ncbi.nlm.nih.gov/pubmed/33791110
http://dx.doi.org/10.15557/JoU.2021.0001
_version_ 1783672637893902336
author Martinez, Jessica A.
Taljanovic, Mihra S.
Witte, Russell S.
Nuncio Zuniga, Andres A.
Wertheim, Betsy C.
Kwoh, C. Kent
Goldstein, Brian A.
Roe, Denise J.
Chalasani, Pavani
author_facet Martinez, Jessica A.
Taljanovic, Mihra S.
Witte, Russell S.
Nuncio Zuniga, Andres A.
Wertheim, Betsy C.
Kwoh, C. Kent
Goldstein, Brian A.
Roe, Denise J.
Chalasani, Pavani
author_sort Martinez, Jessica A.
collection PubMed
description AIM: To determine whether differences in joint and tendon stiffness as measured by ultrasound shear wave elastography are present in breast cancer patients with aromatase inhibitor-associated arthralgias compared to age-comparable healthy control women. METHODS: Postmenopausal women with stage I–III breast cancer who were taking adjuvant aromatase inhibitors and complained of joint pain were enrolled (n = 6). Postmenopausal women with no history of breast cancer, hormone treatment, or joint pain served as controls (n = 7). All subjects had bilateral hands and wrists evaluated by gray-scale and power Doppler ultrasound, and shear wave elastography ultrasound. RESULTS: Patients with AI-associated arthralgias had significantly stiffer tendons than controls in the 1(st) extensor compartment (long axis; p = 0.001), 4(th) extensor compartment (long axis; p = 0.014), 3(rd) metacarpophalangeal joint (p = 0.002), the pooled values of the extensor compartments, both long (p = 0.044) and short axes (p = 0.035), and the pooled values for the metacarpophalangeal joints (p = 0.002). On ultrasound, the patients (but not controls) presented with hyperemia and increased tenosynovial fluid in the flexor and extensor tendon sheaths, and the median nerves were symptomatic and bifid; however, these differences were not statistically significant. CONCLUSIONS: This is the first study to identify increased tendon stiffness as a putative physiological characteristic of aromatase inhibitor–associated arthralgias. Future studies should determine whether increased tendon stiffness is a risk factor for the development of aromatase inhibitor–associated arthralgias, or a result of aromatase inhibitor treatment.
format Online
Article
Text
id pubmed-8008134
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Exeley Inc.
record_format MEDLINE/PubMed
spelling pubmed-80081342021-03-30 Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study Martinez, Jessica A. Taljanovic, Mihra S. Witte, Russell S. Nuncio Zuniga, Andres A. Wertheim, Betsy C. Kwoh, C. Kent Goldstein, Brian A. Roe, Denise J. Chalasani, Pavani J Ultrason Medicine AIM: To determine whether differences in joint and tendon stiffness as measured by ultrasound shear wave elastography are present in breast cancer patients with aromatase inhibitor-associated arthralgias compared to age-comparable healthy control women. METHODS: Postmenopausal women with stage I–III breast cancer who were taking adjuvant aromatase inhibitors and complained of joint pain were enrolled (n = 6). Postmenopausal women with no history of breast cancer, hormone treatment, or joint pain served as controls (n = 7). All subjects had bilateral hands and wrists evaluated by gray-scale and power Doppler ultrasound, and shear wave elastography ultrasound. RESULTS: Patients with AI-associated arthralgias had significantly stiffer tendons than controls in the 1(st) extensor compartment (long axis; p = 0.001), 4(th) extensor compartment (long axis; p = 0.014), 3(rd) metacarpophalangeal joint (p = 0.002), the pooled values of the extensor compartments, both long (p = 0.044) and short axes (p = 0.035), and the pooled values for the metacarpophalangeal joints (p = 0.002). On ultrasound, the patients (but not controls) presented with hyperemia and increased tenosynovial fluid in the flexor and extensor tendon sheaths, and the median nerves were symptomatic and bifid; however, these differences were not statistically significant. CONCLUSIONS: This is the first study to identify increased tendon stiffness as a putative physiological characteristic of aromatase inhibitor–associated arthralgias. Future studies should determine whether increased tendon stiffness is a risk factor for the development of aromatase inhibitor–associated arthralgias, or a result of aromatase inhibitor treatment. Exeley Inc. 2021 2021-03-08 /pmc/articles/PMC8008134/ /pubmed/33791110 http://dx.doi.org/10.15557/JoU.2021.0001 Text en © Polish Ultrasound Society http://creativecommons.org/licenses/cc-by-nc-nd/4.0/ http://creativecommons.org/licenses/cc-by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial NoDerivatives License (CC BY-NC-ND). Reproduction is permitted for personal, educational, non-commercial use, provided that the original article is in whole, unmodified, and properly cited.
spellingShingle Medicine
Martinez, Jessica A.
Taljanovic, Mihra S.
Witte, Russell S.
Nuncio Zuniga, Andres A.
Wertheim, Betsy C.
Kwoh, C. Kent
Goldstein, Brian A.
Roe, Denise J.
Chalasani, Pavani
Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study
title Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study
title_full Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study
title_fullStr Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study
title_full_unstemmed Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study
title_short Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study
title_sort shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008134/
https://www.ncbi.nlm.nih.gov/pubmed/33791110
http://dx.doi.org/10.15557/JoU.2021.0001
work_keys_str_mv AT martinezjessicaa shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy
AT taljanovicmihras shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy
AT witterussells shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy
AT nunciozunigaandresa shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy
AT wertheimbetsyc shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy
AT kwohckent shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy
AT goldsteinbriana shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy
AT roedenisej shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy
AT chalasanipavani shearwaveelastographydetectsnovelimagingbiomarkersofaromataseinhibitorinducedjointpainapilotstudy