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Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue
Fertility preservation represents one important goal of cancer patients’ management due to the high impact on health and quality of life of survivors. The available preventive measures cannot be performed in all patients and are not feasible in all health-care facilities. Therefore, the pharmacologi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008167/ https://www.ncbi.nlm.nih.gov/pubmed/33796467 http://dx.doi.org/10.3389/fonc.2021.641450 |
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author | Brancati, Serena Gozzo, Lucia Longo, Laura Vitale, Daniela Cristina Russo, Giovanna Drago, Filippo |
author_facet | Brancati, Serena Gozzo, Lucia Longo, Laura Vitale, Daniela Cristina Russo, Giovanna Drago, Filippo |
author_sort | Brancati, Serena |
collection | PubMed |
description | Fertility preservation represents one important goal of cancer patients’ management due to the high impact on health and quality of life of survivors. The available preventive measures cannot be performed in all patients and are not feasible in all health-care facilities. Therefore, the pharmacological treatment with GnRHa has become a valuable non-invasive and well-tolerated alternative, especially in those who cannot access to cryopreservation options due to clinical and/or logistic issues. Supporting data demonstrate a significant advantage for the survivors who received GnRHa in the long-term maintenance of ovarian function and preservation of fertility. The prevention of the risk of ovarian failure with GnRHa is a typical off-label use, defined as the administration of a medicinal product not in accordance with the authorized product information. Italy has officially recognized the off-label use of GnRHa in adult women at risk of premature and permanent menopause following chemotherapy. However, fertility preservation still represents an unmet medical need in adolescents who cannot access to other treatment options. |
format | Online Article Text |
id | pubmed-8008167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80081672021-03-31 Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue Brancati, Serena Gozzo, Lucia Longo, Laura Vitale, Daniela Cristina Russo, Giovanna Drago, Filippo Front Oncol Oncology Fertility preservation represents one important goal of cancer patients’ management due to the high impact on health and quality of life of survivors. The available preventive measures cannot be performed in all patients and are not feasible in all health-care facilities. Therefore, the pharmacological treatment with GnRHa has become a valuable non-invasive and well-tolerated alternative, especially in those who cannot access to cryopreservation options due to clinical and/or logistic issues. Supporting data demonstrate a significant advantage for the survivors who received GnRHa in the long-term maintenance of ovarian function and preservation of fertility. The prevention of the risk of ovarian failure with GnRHa is a typical off-label use, defined as the administration of a medicinal product not in accordance with the authorized product information. Italy has officially recognized the off-label use of GnRHa in adult women at risk of premature and permanent menopause following chemotherapy. However, fertility preservation still represents an unmet medical need in adolescents who cannot access to other treatment options. Frontiers Media S.A. 2021-03-09 /pmc/articles/PMC8008167/ /pubmed/33796467 http://dx.doi.org/10.3389/fonc.2021.641450 Text en Copyright © 2021 Brancati, Gozzo, Longo, Vitale, Russo and Drago http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Brancati, Serena Gozzo, Lucia Longo, Laura Vitale, Daniela Cristina Russo, Giovanna Drago, Filippo Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue |
title | Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue |
title_full | Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue |
title_fullStr | Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue |
title_full_unstemmed | Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue |
title_short | Fertility Preservation in Female Pediatric Patients With Cancer: A Clinical and Regulatory Issue |
title_sort | fertility preservation in female pediatric patients with cancer: a clinical and regulatory issue |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008167/ https://www.ncbi.nlm.nih.gov/pubmed/33796467 http://dx.doi.org/10.3389/fonc.2021.641450 |
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