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Temporal metabolic and transcriptomic characteristics crossing islets and liver reveal dynamic pathophysiology in diet-induced diabetes

To investigate the molecular mechanisms underlying islet dysfunction and insulin resistance in diet-induced diabetes, we conducted temporal RNA sequencing of tissues responsible for insulin secretion (islets) and action (liver) every 4 weeks in mice on high-fat (HFD) or chow diet for 24 weeks, linki...

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Detalles Bibliográficos
Autores principales:	Gao, Rui, Fu, Qi, Jiang, He-Min, Shen, Min, Zhao, Rui-Ling, Qian, Yu, He, Yun-Qiang, Xu, Kuan-Feng, Xu, Xin-Yu, Chen, Heng, Zhang, Quan, Yang, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008187/ https://www.ncbi.nlm.nih.gov/pubmed/33817571 http://dx.doi.org/10.1016/j.isci.2021.102265

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