Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing aortic rupture. During AAA formation, pathological vascular remodeling is driven by macrophage infiltration, and the mechanisms regulating macrophage-mediated inflammation remai...

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Detalles Bibliográficos
Autores principales: Davis, Frank M., Tsoi, Lam C., Melvin, William J., denDekker, Aaron, Wasikowski, Rachael, Joshi, Amrita D., Wolf, Sonya, Obi, Andrea T., Billi, Allison C., Xing, Xianying, Audu, Christopher, Moore, Bethany B., Kunkel, Steven L., Daugherty, Alan, Lu, Hong S., Gudjonsson, Johann E., Gallagher, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008365/
https://www.ncbi.nlm.nih.gov/pubmed/33779682
http://dx.doi.org/10.1084/jem.20201839

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