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Alzheimer’s Disease in Patients with Obstructive Sleep Apnea Syndrome
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a disorder with high prevalence among adults and is an independent risk factor for various diseases, especially those affecting the central nervous system (CNS). Continuous positive airway pressure (CPAP) is usually the optimal choice of treatme...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Research Institute of Tuberculosis and Lung Disease
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008406/ https://www.ncbi.nlm.nih.gov/pubmed/33815537 |
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author | Siachpazidou, Dimitra I. Stavrou, Vasileios T. Astara, Kyriaki Pastaka, Chaido Gogou, Eudoxia Hatzoglou, Chrissi Economou, Nicholas-Tiberio Gourgoulianis, Konstantinos I. |
author_facet | Siachpazidou, Dimitra I. Stavrou, Vasileios T. Astara, Kyriaki Pastaka, Chaido Gogou, Eudoxia Hatzoglou, Chrissi Economou, Nicholas-Tiberio Gourgoulianis, Konstantinos I. |
author_sort | Siachpazidou, Dimitra I. |
collection | PubMed |
description | BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a disorder with high prevalence among adults and is an independent risk factor for various diseases, especially those affecting the central nervous system (CNS). Continuous positive airway pressure (CPAP) is usually the optimal choice of treatment for OSAS. Alzheimer’s disease (AD) is a neurodegenerative disease affecting a large proportion of the elderly population. The purpose of this study was to collect information concerning the two pathological entities and investigate the effectiveness of CPAP in the treatment of AD. MATERIALS AND METHODS: In this review, Twenty articles were found concerning OSAS and AD, of which one article was about treatment with donepezil and seven articles considered treatment with CPAP. RESULTS: Serious OSAS and short sleep duration are associated with a high risk of developing dementia. Respiratory distress during sleep is associated with developing mild cognitive impairment at younger ages. The cerebrovascular damage of AD patients is correlated with the severity of OSAS. Lower cerebrospinal fluid levels are associated with memory disturbances and oxygen saturation parameters in patients with OSAS-AD. Continuous use of CPAP is related to the delayed onset of cognitive impairment and is suggested as an effective method of protecting cognitive function, depression, sleep quality and architecture, and daytime sleepiness in AD patients with good compliance. Treatment of CPAP patients with OSAS-AD is suggested as an effective method of protecting cognitive function. CONCLUSION: Clinicians dealing with AD patients should consider CPAP treatment when OSAS coexists. |
format | Online Article Text |
id | pubmed-8008406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | National Research Institute of Tuberculosis and Lung Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-80084062021-04-02 Alzheimer’s Disease in Patients with Obstructive Sleep Apnea Syndrome Siachpazidou, Dimitra I. Stavrou, Vasileios T. Astara, Kyriaki Pastaka, Chaido Gogou, Eudoxia Hatzoglou, Chrissi Economou, Nicholas-Tiberio Gourgoulianis, Konstantinos I. Tanaffos Review Article BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a disorder with high prevalence among adults and is an independent risk factor for various diseases, especially those affecting the central nervous system (CNS). Continuous positive airway pressure (CPAP) is usually the optimal choice of treatment for OSAS. Alzheimer’s disease (AD) is a neurodegenerative disease affecting a large proportion of the elderly population. The purpose of this study was to collect information concerning the two pathological entities and investigate the effectiveness of CPAP in the treatment of AD. MATERIALS AND METHODS: In this review, Twenty articles were found concerning OSAS and AD, of which one article was about treatment with donepezil and seven articles considered treatment with CPAP. RESULTS: Serious OSAS and short sleep duration are associated with a high risk of developing dementia. Respiratory distress during sleep is associated with developing mild cognitive impairment at younger ages. The cerebrovascular damage of AD patients is correlated with the severity of OSAS. Lower cerebrospinal fluid levels are associated with memory disturbances and oxygen saturation parameters in patients with OSAS-AD. Continuous use of CPAP is related to the delayed onset of cognitive impairment and is suggested as an effective method of protecting cognitive function, depression, sleep quality and architecture, and daytime sleepiness in AD patients with good compliance. Treatment of CPAP patients with OSAS-AD is suggested as an effective method of protecting cognitive function. CONCLUSION: Clinicians dealing with AD patients should consider CPAP treatment when OSAS coexists. National Research Institute of Tuberculosis and Lung Disease 2020-07 /pmc/articles/PMC8008406/ /pubmed/33815537 Text en Copyright© 2020 National Research Institute of Tuberculosis and Lung Disease This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Review Article Siachpazidou, Dimitra I. Stavrou, Vasileios T. Astara, Kyriaki Pastaka, Chaido Gogou, Eudoxia Hatzoglou, Chrissi Economou, Nicholas-Tiberio Gourgoulianis, Konstantinos I. Alzheimer’s Disease in Patients with Obstructive Sleep Apnea Syndrome |
title | Alzheimer’s Disease in Patients with Obstructive Sleep Apnea Syndrome |
title_full | Alzheimer’s Disease in Patients with Obstructive Sleep Apnea Syndrome |
title_fullStr | Alzheimer’s Disease in Patients with Obstructive Sleep Apnea Syndrome |
title_full_unstemmed | Alzheimer’s Disease in Patients with Obstructive Sleep Apnea Syndrome |
title_short | Alzheimer’s Disease in Patients with Obstructive Sleep Apnea Syndrome |
title_sort | alzheimer’s disease in patients with obstructive sleep apnea syndrome |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008406/ https://www.ncbi.nlm.nih.gov/pubmed/33815537 |
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