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Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action

[Image: see text] The “tail approach” has become a milestone in human carbonic anhydrase inhibitor (hCAI) design for various therapeutics, including antiglaucoma agents. Besides the classical hydrophobic/hydrophilic division of hCAs active site, several subpockets have been identified at the middle/...

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Detalles Bibliográficos
Autores principales:	Bonardi, Alessandro, Nocentini, Alessio, Bua, Silvia, Combs, Jacob, Lomelino, Carrie, Andring, Jacob, Lucarini, Laura, Sgambellone, Silvia, Masini, Emanuela, McKenna, Robert, Gratteri, Paola, Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008423/ https://www.ncbi.nlm.nih.gov/pubmed/32519851 http://dx.doi.org/10.1021/acs.jmedchem.0c00733

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