Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design

[Image: see text] The Mg(2+)-dependent Mycobacterium tuberculosis salicylate synthase (MbtI) is a key enzyme involved in the biosynthesis of siderophores. Because iron is essential for the survival and pathogenicity of the microorganism, this protein constitutes an attractive target for antitubercul...

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Detalles Bibliográficos
Autores principales: Mori, Matteo, Stelitano, Giovanni, Gelain, Arianna, Pini, Elena, Chiarelli, Laurent R., Sammartino, José C., Poli, Giulio, Tuccinardi, Tiziano, Beretta, Giangiacomo, Porta, Alessio, Bellinzoni, Marco, Villa, Stefania, Meneghetti, Fiorella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008425/
https://www.ncbi.nlm.nih.gov/pubmed/32530281
http://dx.doi.org/10.1021/acs.jmedchem.0c00373

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