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Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma

BACKGROUND: Frailty is an important consideration for older patients undergoing surgery. We aimed to investigate whether frailty could be a prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent pancreatic resection. METHODS: One hundred and twenty patients who underwent p...

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Autores principales: Yamada, Shinichiro, Shimada, Mitsuo, Morine, Yuji, Imura, Satoru, Ikemoto, Tetsuya, Saito, Yu, Miyazaki, Katsuki, Tokunaga, Takuya, Nishi, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008590/
https://www.ncbi.nlm.nih.gov/pubmed/33781262
http://dx.doi.org/10.1186/s12957-021-02205-6
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author Yamada, Shinichiro
Shimada, Mitsuo
Morine, Yuji
Imura, Satoru
Ikemoto, Tetsuya
Saito, Yu
Miyazaki, Katsuki
Tokunaga, Takuya
Nishi, Masaaki
author_facet Yamada, Shinichiro
Shimada, Mitsuo
Morine, Yuji
Imura, Satoru
Ikemoto, Tetsuya
Saito, Yu
Miyazaki, Katsuki
Tokunaga, Takuya
Nishi, Masaaki
author_sort Yamada, Shinichiro
collection PubMed
description BACKGROUND: Frailty is an important consideration for older patients undergoing surgery. We aimed to investigate whether frailty could be a prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent pancreatic resection. METHODS: One hundred and twenty patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma were enrolled. Frailty was defined as a clinical frailty scale score ≥4. Patients were divided into frailty (n = 29) and non-frailty (n=91) groups, and clinicopathological factors were compared between the two groups. RESULTS: The frailty group showed an older age, lower serum albumin concentration, lower prognostic nutritional index, larger tumor diameter, and higher rate of lymph node metastasis than the non-frailty group (p < 0.05). Neutrophil–lymphocyte ratio and modified Glasgow prognostic score tended to be higher in the frailty group. Cancer-specific and disease-free survival rates were significantly poor in the frailty group (p < 0.05). With a multivariate analysis, frailty was an independent prognostic factor of cancer-specific survival. CONCLUSIONS: Frailty can predict the prognosis of patients with pancreatic ductal adenocarcinoma who undergo pancreatic resection.
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spelling pubmed-80085902021-03-30 Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma Yamada, Shinichiro Shimada, Mitsuo Morine, Yuji Imura, Satoru Ikemoto, Tetsuya Saito, Yu Miyazaki, Katsuki Tokunaga, Takuya Nishi, Masaaki World J Surg Oncol Research BACKGROUND: Frailty is an important consideration for older patients undergoing surgery. We aimed to investigate whether frailty could be a prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent pancreatic resection. METHODS: One hundred and twenty patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma were enrolled. Frailty was defined as a clinical frailty scale score ≥4. Patients were divided into frailty (n = 29) and non-frailty (n=91) groups, and clinicopathological factors were compared between the two groups. RESULTS: The frailty group showed an older age, lower serum albumin concentration, lower prognostic nutritional index, larger tumor diameter, and higher rate of lymph node metastasis than the non-frailty group (p < 0.05). Neutrophil–lymphocyte ratio and modified Glasgow prognostic score tended to be higher in the frailty group. Cancer-specific and disease-free survival rates were significantly poor in the frailty group (p < 0.05). With a multivariate analysis, frailty was an independent prognostic factor of cancer-specific survival. CONCLUSIONS: Frailty can predict the prognosis of patients with pancreatic ductal adenocarcinoma who undergo pancreatic resection. BioMed Central 2021-03-29 /pmc/articles/PMC8008590/ /pubmed/33781262 http://dx.doi.org/10.1186/s12957-021-02205-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yamada, Shinichiro
Shimada, Mitsuo
Morine, Yuji
Imura, Satoru
Ikemoto, Tetsuya
Saito, Yu
Miyazaki, Katsuki
Tokunaga, Takuya
Nishi, Masaaki
Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma
title Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma
title_full Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma
title_fullStr Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma
title_full_unstemmed Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma
title_short Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma
title_sort significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008590/
https://www.ncbi.nlm.nih.gov/pubmed/33781262
http://dx.doi.org/10.1186/s12957-021-02205-6
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