A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma

BACKGROUND: Lymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play a key role in carcinogenesis and tumor development by enhancing invasiveness and promoting lymph node metastasis. The purpose of this stud...

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Autores principales: Wang, Yanping, Wang, Jikun, Yang, Chunyu, Wang, Yue, Liu, Jinhao, Shi, Zuoxiu, Chen, Yanlei, Feng, Yang, Ma, Xueqian, Qiao, Shifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008636/
https://www.ncbi.nlm.nih.gov/pubmed/33781288
http://dx.doi.org/10.1186/s12957-021-02195-5
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author Wang, Yanping
Wang, Jikun
Yang, Chunyu
Wang, Yue
Liu, Jinhao
Shi, Zuoxiu
Chen, Yanlei
Feng, Yang
Ma, Xueqian
Qiao, Shifeng
author_facet Wang, Yanping
Wang, Jikun
Yang, Chunyu
Wang, Yue
Liu, Jinhao
Shi, Zuoxiu
Chen, Yanlei
Feng, Yang
Ma, Xueqian
Qiao, Shifeng
author_sort Wang, Yanping
collection PubMed
description BACKGROUND: Lymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play a key role in carcinogenesis and tumor development by enhancing invasiveness and promoting lymph node metastasis. The purpose of this study was to investigate the effect of CD163-positive M2 macrophages on lymph node metastasis in colorectal carcinoma. METHODS: Postoperative lymph node tissues were obtained from 120 patients with colorectal carcinoma who underwent radical surgery in the First Affiliated Hospital of Jinzhou Medical University between December 2019 and May 2020. We detected the expression of the CD163 protein in lymph nodes using immunohistochemistry. Furthermore, the relationships between M2 macrophages identified by expression of CD163 and lymph node metastasis were analyzed using the independent sample t-test and Chi-square test. RESULTS: M2 macrophages were increased in metastatic lymph nodes and non-metastatic lymph nodes adjacent to the cancer. The M2 macrophage count was higher in patients with macro-metastases than in patients with micro-metastases. CONCLUSIONS: The presence of M2 macrophages represents an important indicator for lymph node metastasis in colorectal carcinoma and may be a potential marker for its prediction. Thus, M2 macrophage localization might offer a new target for the comprehensive treatment of colorectal carcinoma.
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spelling pubmed-80086362021-03-31 A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma Wang, Yanping Wang, Jikun Yang, Chunyu Wang, Yue Liu, Jinhao Shi, Zuoxiu Chen, Yanlei Feng, Yang Ma, Xueqian Qiao, Shifeng World J Surg Oncol Research BACKGROUND: Lymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play a key role in carcinogenesis and tumor development by enhancing invasiveness and promoting lymph node metastasis. The purpose of this study was to investigate the effect of CD163-positive M2 macrophages on lymph node metastasis in colorectal carcinoma. METHODS: Postoperative lymph node tissues were obtained from 120 patients with colorectal carcinoma who underwent radical surgery in the First Affiliated Hospital of Jinzhou Medical University between December 2019 and May 2020. We detected the expression of the CD163 protein in lymph nodes using immunohistochemistry. Furthermore, the relationships between M2 macrophages identified by expression of CD163 and lymph node metastasis were analyzed using the independent sample t-test and Chi-square test. RESULTS: M2 macrophages were increased in metastatic lymph nodes and non-metastatic lymph nodes adjacent to the cancer. The M2 macrophage count was higher in patients with macro-metastases than in patients with micro-metastases. CONCLUSIONS: The presence of M2 macrophages represents an important indicator for lymph node metastasis in colorectal carcinoma and may be a potential marker for its prediction. Thus, M2 macrophage localization might offer a new target for the comprehensive treatment of colorectal carcinoma. BioMed Central 2021-03-29 /pmc/articles/PMC8008636/ /pubmed/33781288 http://dx.doi.org/10.1186/s12957-021-02195-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Yanping
Wang, Jikun
Yang, Chunyu
Wang, Yue
Liu, Jinhao
Shi, Zuoxiu
Chen, Yanlei
Feng, Yang
Ma, Xueqian
Qiao, Shifeng
A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma
title A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma
title_full A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma
title_fullStr A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma
title_full_unstemmed A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma
title_short A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma
title_sort study of the correlation between m2 macrophages and lymph node metastasis of colorectal carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008636/
https://www.ncbi.nlm.nih.gov/pubmed/33781288
http://dx.doi.org/10.1186/s12957-021-02195-5
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