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Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases
Chronic respiratory diseases account for high morbidity and mortality, with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) being the most prevalent globally. Even though the diseases increase in prevalence, the exact underlying mechanisms have still not been fully und...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Exeley Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008760/ https://www.ncbi.nlm.nih.gov/pubmed/33815524 http://dx.doi.org/10.33073/pjm-2021-013 |
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author | MAGRYŚ, AGNIESZKA |
author_facet | MAGRYŚ, AGNIESZKA |
author_sort | MAGRYŚ, AGNIESZKA |
collection | PubMed |
description | Chronic respiratory diseases account for high morbidity and mortality, with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) being the most prevalent globally. Even though the diseases increase in prevalence, the exact underlying mechanisms have still not been fully understood. Despite their differences in nature, pathophysiologies, and clinical phenotypes, a growing body of evidence indicates that the presence of lung microbiota can shape the pathogenic processes underlying chronic inflammation, typically observed in the course of the diseases. Therefore, the characterization of the lung microbiota may shed new light on the pathogenesis of these diseases. Specifically, in chronic respiratory tract diseases, the human microbiota may contribute to the disease’s development and severity. The present review explores the role of the microbiota in the area of chronic pulmonary diseases, especially COPD, asthma, and CF. |
format | Online Article Text |
id | pubmed-8008760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Exeley Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80087602021-04-01 Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases MAGRYŚ, AGNIESZKA Pol J Microbiol Microbiology Chronic respiratory diseases account for high morbidity and mortality, with asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) being the most prevalent globally. Even though the diseases increase in prevalence, the exact underlying mechanisms have still not been fully understood. Despite their differences in nature, pathophysiologies, and clinical phenotypes, a growing body of evidence indicates that the presence of lung microbiota can shape the pathogenic processes underlying chronic inflammation, typically observed in the course of the diseases. Therefore, the characterization of the lung microbiota may shed new light on the pathogenesis of these diseases. Specifically, in chronic respiratory tract diseases, the human microbiota may contribute to the disease’s development and severity. The present review explores the role of the microbiota in the area of chronic pulmonary diseases, especially COPD, asthma, and CF. Exeley Inc. 2021-03 2021-03-19 /pmc/articles/PMC8008760/ /pubmed/33815524 http://dx.doi.org/10.33073/pjm-2021-013 Text en © 2021 Agnieszka Magryś https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Microbiology MAGRYŚ, AGNIESZKA Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases |
title | Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases |
title_full | Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases |
title_fullStr | Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases |
title_full_unstemmed | Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases |
title_short | Microbiota: A Missing Link in The Pathogenesis of Chronic Lung Inflammatory Diseases |
title_sort | microbiota: a missing link in the pathogenesis of chronic lung inflammatory diseases |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008760/ https://www.ncbi.nlm.nih.gov/pubmed/33815524 http://dx.doi.org/10.33073/pjm-2021-013 |
work_keys_str_mv | AT magrysagnieszka microbiotaamissinglinkinthepathogenesisofchroniclunginflammatorydiseases |