Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil

INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METH...

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Detalles Bibliográficos
Autores principales: Siconelli, Márcio Junio Lima, Jorge, Daniel Macedo de Melo, de Castro-Jorge, Luiza Antunes, Fonseca-Júnior, Antônio Augusto, Nascimento, Mateus Laguardia, Floriano, Vitor Gonçalves, de Souza, Fransérgio Rocha, de Queiroz-Júnior, Eudson Maia, Camargos, Marcelo Fernandes, Costa, Eliana Dea Lara, Carvalho, Adolorata Aparecida Bianco, da Fonseca, Benedito Antonio Lopes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008906/
https://www.ncbi.nlm.nih.gov/pubmed/33681933
http://dx.doi.org/10.1590/0037-8682-0687-2020
Descripción
Sumario:INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.

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