Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil

INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METH...

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Autores principales: Siconelli, Márcio Junio Lima, Jorge, Daniel Macedo de Melo, de Castro-Jorge, Luiza Antunes, Fonseca-Júnior, Antônio Augusto, Nascimento, Mateus Laguardia, Floriano, Vitor Gonçalves, de Souza, Fransérgio Rocha, de Queiroz-Júnior, Eudson Maia, Camargos, Marcelo Fernandes, Costa, Eliana Dea Lara, Carvalho, Adolorata Aparecida Bianco, da Fonseca, Benedito Antonio Lopes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008906/
https://www.ncbi.nlm.nih.gov/pubmed/33681933
http://dx.doi.org/10.1590/0037-8682-0687-2020
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author Siconelli, Márcio Junio Lima
Jorge, Daniel Macedo de Melo
de Castro-Jorge, Luiza Antunes
Fonseca-Júnior, Antônio Augusto
Nascimento, Mateus Laguardia
Floriano, Vitor Gonçalves
de Souza, Fransérgio Rocha
de Queiroz-Júnior, Eudson Maia
Camargos, Marcelo Fernandes
Costa, Eliana Dea Lara
Carvalho, Adolorata Aparecida Bianco
da Fonseca, Benedito Antonio Lopes
author_facet Siconelli, Márcio Junio Lima
Jorge, Daniel Macedo de Melo
de Castro-Jorge, Luiza Antunes
Fonseca-Júnior, Antônio Augusto
Nascimento, Mateus Laguardia
Floriano, Vitor Gonçalves
de Souza, Fransérgio Rocha
de Queiroz-Júnior, Eudson Maia
Camargos, Marcelo Fernandes
Costa, Eliana Dea Lara
Carvalho, Adolorata Aparecida Bianco
da Fonseca, Benedito Antonio Lopes
author_sort Siconelli, Márcio Junio Lima
collection PubMed
description INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.
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spelling pubmed-80089062021-04-01 Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil Siconelli, Márcio Junio Lima Jorge, Daniel Macedo de Melo de Castro-Jorge, Luiza Antunes Fonseca-Júnior, Antônio Augusto Nascimento, Mateus Laguardia Floriano, Vitor Gonçalves de Souza, Fransérgio Rocha de Queiroz-Júnior, Eudson Maia Camargos, Marcelo Fernandes Costa, Eliana Dea Lara Carvalho, Adolorata Aparecida Bianco da Fonseca, Benedito Antonio Lopes Rev Soc Bras Med Trop Short Communication INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years. Sociedade Brasileira de Medicina Tropical - SBMT 2021-03-08 /pmc/articles/PMC8008906/ /pubmed/33681933 http://dx.doi.org/10.1590/0037-8682-0687-2020 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Siconelli, Márcio Junio Lima
Jorge, Daniel Macedo de Melo
de Castro-Jorge, Luiza Antunes
Fonseca-Júnior, Antônio Augusto
Nascimento, Mateus Laguardia
Floriano, Vitor Gonçalves
de Souza, Fransérgio Rocha
de Queiroz-Júnior, Eudson Maia
Camargos, Marcelo Fernandes
Costa, Eliana Dea Lara
Carvalho, Adolorata Aparecida Bianco
da Fonseca, Benedito Antonio Lopes
Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_full Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_fullStr Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_full_unstemmed Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_short Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_sort evidence for current circulation of an ancient west nile virus strain (ny99) in brazil
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008906/
https://www.ncbi.nlm.nih.gov/pubmed/33681933
http://dx.doi.org/10.1590/0037-8682-0687-2020
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