Cargando…

Transition metal-catalysed A-ring C–H activations and C(sp(2))–C(sp(2)) couplings in the 13α-oestrone series and in vitro evaluation of antiproliferative properties

Facile syntheses of 3-O-carbamoyl, -sulfamoyl, or -pivaloyl derivatives of 13α-oestrone and its 17-deoxy counterpart have been carried out. Microwave-induced, Ni-catalysed Suzuki–Miyaura couplings of the newly synthesised phenol esters with phenylboronic acid afforded 3-deoxy-3-phenyl-13α-oestrone d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Traj, Péter, Abdolkhaliq, Ali Hazhmat, Németh, Anett, Dajcs, Sámuel Trisztán, Tömösi, Ferenc, Lanisnik-Rizner, Tea, Zupkó, István, Mernyák, Erzsébet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008932/ https://www.ncbi.nlm.nih.gov/pubmed/33771084 http://dx.doi.org/10.1080/14756366.2021.1900165

Ejemplares similares

Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
por: Sinreih, Maša, et al.
Publicado: (2021)

Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers
por: Kovács, Édua, et al.
Publicado: (2023)

Microwave-assisted Phospha-Michael addition reactions in the 13α-oestrone series and in vitro antiproliferative properties
por: Mernyák, Erzsébet, et al.
Publicado: (2021)

Investigation of the Antineoplastic Effects of 2-(4-Chlorophenyl)-13α-Estrone Sulfamate against the HPV16-Positive Human Invasive Cervical Carcinoma Cell Line SiHa
por: Ali, Hazhmat, et al.
Publicado: (2023)

Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives
por: Jójárt, Rebeka, et al.
Publicado: (2020)

Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
por: Rižner, Tea Lanišnik
Publicado: (2012)

Rhodium-catalysed C(sp(2))–C(sp(2)) bond formation via C–H/C–F activation
por: Tian, Panpan, et al.
Publicado: (2015)

Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative
por: Szabó, Johanna, et al.
Publicado: (2016)

Iron-Catalysed C(sp(2))-H Borylation Enabled by Carboxylate Activation
por: Britton, Luke, et al.
Publicado: (2020)

Multimetallic catalysed radical oxidative C(sp(3))–H/C(sp)–H cross-coupling between unactivated alkanes and terminal alkynes
por: Tang, Shan, et al.
Publicado: (2016)

The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases
por: Rižner, Tea Lanišnik
Publicado: (2016)

Editorial: Relevance of Steroid Biosynthesis, Metabolism and Transport in Pathophysiology and Drug Discovery
por: Rižner, Tea Lanišnik
Publicado: (2019)

Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity
por: Gyovai, András, et al.
Publicado: (2018)

AKR1C3 Is Associated with Better Survival of Patients with Endometrial Carcinomas
por: Hojnik, Marko, et al.
Publicado: (2020)

Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis
por: Bacsa, Ildikó, et al.
Publicado: (2018)

Estrogens and the Schrödinger’s Cat in the Ovarian Tumor Microenvironment
por: Gjorgoska, Marija, et al.
Publicado: (2021)

Targeting the formation of estrogens for treatment of hormone dependent diseases–current status
por: Rižner, Tea Lanišnik, et al.
Publicado: (2023)

Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp(3) C–H functionalization
por: Zhang, Ruijie K., et al.
Publicado: (2018)

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide.
por: LÃ¸nning, P. E., et al.
Publicado: (1989)

The Action of Oestrone and Four Chemical Carcinogens in Intact and Ovariectomised BALB/c/Cb/Se Mice
por: Biancifiori, C., et al.
Publicado: (1967)

Site-Selective C(sp(3))–C(sp)/C(sp(3))–C(sp(2)) Cross-Coupling Reactions Using Frustrated Lewis Pairs
por: Dasgupta, Ayan, et al.
Publicado: (2021)

Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs †
por: Senobar Tahaei, Seyyed Ashkan, et al.
Publicado: (2023)

Editorial: Women in experimental pharmacology and drug discovery: 2021
por: Rižner, Tea Lanišnik, et al.
Publicado: (2022)

Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line
por: Kljun, Jakob, et al.
Publicado: (2022)

The Effect of Oestrone on the Incidence of Mammary Carcinoma and Adenoma in C(3)Hf Breeders After Late Ovariectomy
por: Pullinger, B. D.
Publicado: (1961)

Mammary Carcinoma Incidence in C(3)Hf Virgin Female Mice after Ovariectomy and Substituted Oestrone
por: Pullinger, B. D.
Publicado: (1959)

Recent Advances in C(sp(3))–C(sp(3)) and C(sp(3))–C(sp(2)) Bond Formation through Cathodic Reactions: Reductive and Convergent Paired Electrolyses
por: Claraz, Aurélie, et al.
Publicado: (2021)

Metabolomics for Diagnosis and Prognosis of Uterine Diseases? A Systematic Review
por: Tokarz, Janina, et al.
Publicado: (2020)

Model Cell Lines and Tissues of Different HGSOC Subtypes Differ in Local Estrogen Biosynthesis
por: Pavlič, Renata, et al.
Publicado: (2022)

The first Pd-catalyzed Buchwald–Hartwig aminations at C-2 or C-4 in the estrone series
por: Bacsa, Ildikó, et al.
Publicado: (2018)

Practical Catalytic Cleavage of C(sp(3))−C(sp(3)) Bonds in Amines
por: Li, Wu, et al.
Publicado: (2019)

The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers
por: Rižner, Tea Lanišnik, et al.
Publicado: (2017)

Visible light-mediated gold-catalysed carbon(sp(2))–carbon(sp) cross-coupling
por: Kim, Suhong, et al.
Publicado: (2016)

Single operation palladium catalysed C(sp(3))–H functionalisation of tertiary aldehydes: investigations into transient imine directing groups
por: St John-Campbell, S., et al.
Publicado: (2017)

Copper(I)-catalysed site-selective C(sp(3))–H bond chlorination of ketones, (E)-enones and alkylbenzenes by dichloramine-T
por: Jin, Jianwen, et al.
Publicado: (2021)

C(acyl)–C(sp(2)) and C(sp(2))–C(sp(2)) Suzuki–Miyaura cross-coupling reactions using nitrile-functionalized NHC palladium complexes
por: Çakır, Sinem, et al.
Publicado: (2021)

Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates
por: Bacsa, Ildikó, et al.
Publicado: (2018)

Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds
por: Zhu, Ru-Yi, et al.
Publicado: (2014)

Theoretical investigation on the effect of the ligand on bis-silylation of C(sp)–C(sp) by Ni complexes
por: Hui, Li, et al.
Publicado: (2022)

Selective valorization of lignin to phenol by direct transformation of C(sp2)–C(sp3) and C–O bonds
por: Yan, Jiang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vbrdf9frfo3k8evtgopt0hor1k