Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

Arterial stiffening and cardiac dysfunction are hallmarks of premature aging in Hutchinson–Gilford Progeria Syndrome (HGPS), but the molecular regulators remain unknown. Here, we show that the LaminA(G609G) mouse model of HGPS recapitulates the premature arterial stiffening and early diastolic dysfu...

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Detalles Bibliográficos
Autores principales: von Kleeck, Ryan, Roberts, Emilia, Castagnino, Paola, Bruun, Kyle, Brankovic, Sonja A, Hawthorne, Elizabeth A, Xu, Tina, Tobias, John W, Assoian, Richard K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008950/
https://www.ncbi.nlm.nih.gov/pubmed/33687998
http://dx.doi.org/10.26508/lsa.202000997

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