Cargando…

Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure

In early 2020, a novel coronavirus leading to potentially death was discovered. Since then, the 2019 coronavirus disease (COVID-19) has spread to become a worldwide pandemic. Beyond the risks strictly related to the infection, concerns have been expressed for the endocrinological impact that COVID-1...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaudino, Rossella, Orlandi, Valentina, Cavarzere, Paolo, Chinello, Matteo, Antoniazzi, Franco, Cesaro, Simone, Piacentini, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008962/
https://www.ncbi.nlm.nih.gov/pubmed/33796066
http://dx.doi.org/10.3389/fendo.2021.596654
_version_ 1783672792139431936
author Gaudino, Rossella
Orlandi, Valentina
Cavarzere, Paolo
Chinello, Matteo
Antoniazzi, Franco
Cesaro, Simone
Piacentini, Giorgio
author_facet Gaudino, Rossella
Orlandi, Valentina
Cavarzere, Paolo
Chinello, Matteo
Antoniazzi, Franco
Cesaro, Simone
Piacentini, Giorgio
author_sort Gaudino, Rossella
collection PubMed
description In early 2020, a novel coronavirus leading to potentially death was discovered. Since then, the 2019 coronavirus disease (COVID-19) has spread to become a worldwide pandemic. Beyond the risks strictly related to the infection, concerns have been expressed for the endocrinological impact that COVID-19 may have, especially in vulnerable individuals with pre-existing endocrinological health conditions. To date new information is emerging regarding severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in children but the literature is still scarce concerning this infection in patients with intracranial malignant neoplasms. We report a 9-year-old child infected with SARS-CoV-2 and recent diagnosis of suprasellar non-germinomatous germ cell tumor also suffering from diabetes insipidus and hypothalamic-pituitary failure (hypothyroidism, adrenal insufficiency, hypothalamic obesity and growth hormone deficiency) and its clinical course. The patient remained asymptomatic for the duration of the infection without requiring any change in the replacement therapeutic dosages taken before the infection. We then discuss the proposed approach to treat a pediatric patient with SARS-CoV-2 infection and hypothalamic-pituitary failure and we include a review of the literature. Our report suggests that SARS-CoV-2 infection is usually mild and self-limiting in children even those immunocompromised and with multiple endocrinological deficits. Patients are advised to keep any scheduled appointments unless informed otherwise.
format Online
Article
Text
id pubmed-8008962
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80089622021-03-31 Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure Gaudino, Rossella Orlandi, Valentina Cavarzere, Paolo Chinello, Matteo Antoniazzi, Franco Cesaro, Simone Piacentini, Giorgio Front Endocrinol (Lausanne) Endocrinology In early 2020, a novel coronavirus leading to potentially death was discovered. Since then, the 2019 coronavirus disease (COVID-19) has spread to become a worldwide pandemic. Beyond the risks strictly related to the infection, concerns have been expressed for the endocrinological impact that COVID-19 may have, especially in vulnerable individuals with pre-existing endocrinological health conditions. To date new information is emerging regarding severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in children but the literature is still scarce concerning this infection in patients with intracranial malignant neoplasms. We report a 9-year-old child infected with SARS-CoV-2 and recent diagnosis of suprasellar non-germinomatous germ cell tumor also suffering from diabetes insipidus and hypothalamic-pituitary failure (hypothyroidism, adrenal insufficiency, hypothalamic obesity and growth hormone deficiency) and its clinical course. The patient remained asymptomatic for the duration of the infection without requiring any change in the replacement therapeutic dosages taken before the infection. We then discuss the proposed approach to treat a pediatric patient with SARS-CoV-2 infection and hypothalamic-pituitary failure and we include a review of the literature. Our report suggests that SARS-CoV-2 infection is usually mild and self-limiting in children even those immunocompromised and with multiple endocrinological deficits. Patients are advised to keep any scheduled appointments unless informed otherwise. Frontiers Media S.A. 2021-03-16 /pmc/articles/PMC8008962/ /pubmed/33796066 http://dx.doi.org/10.3389/fendo.2021.596654 Text en Copyright © 2021 Gaudino, Orlandi, Cavarzere, Chinello, Antoniazzi, Cesaro and Piacentini http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Gaudino, Rossella
Orlandi, Valentina
Cavarzere, Paolo
Chinello, Matteo
Antoniazzi, Franco
Cesaro, Simone
Piacentini, Giorgio
Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure
title Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure
title_full Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure
title_fullStr Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure
title_full_unstemmed Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure
title_short Case Report: SARS-CoV-2 Infection in a Child With Suprasellar Tumor and Hypothalamic-Pituitary Failure
title_sort case report: sars-cov-2 infection in a child with suprasellar tumor and hypothalamic-pituitary failure
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008962/
https://www.ncbi.nlm.nih.gov/pubmed/33796066
http://dx.doi.org/10.3389/fendo.2021.596654
work_keys_str_mv AT gaudinorossella casereportsarscov2infectioninachildwithsuprasellartumorandhypothalamicpituitaryfailure
AT orlandivalentina casereportsarscov2infectioninachildwithsuprasellartumorandhypothalamicpituitaryfailure
AT cavarzerepaolo casereportsarscov2infectioninachildwithsuprasellartumorandhypothalamicpituitaryfailure
AT chinellomatteo casereportsarscov2infectioninachildwithsuprasellartumorandhypothalamicpituitaryfailure
AT antoniazzifranco casereportsarscov2infectioninachildwithsuprasellartumorandhypothalamicpituitaryfailure
AT cesarosimone casereportsarscov2infectioninachildwithsuprasellartumorandhypothalamicpituitaryfailure
AT piacentinigiorgio casereportsarscov2infectioninachildwithsuprasellartumorandhypothalamicpituitaryfailure