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Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

BACKGROUND: Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1) blockade in colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability (MSI) has never been clarified....

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Detalles Bibliográficos
Autores principales:	Sui, Qiaoqi, Liu, Dingxin, Jiang, Wu, Tang, Jinghua, Kong, Lingheng, Han, Kai, Liao, Leen, Li, Yuan, Ou, Qingjian, Xiao, Binyi, Liu, Guochen, Ling, Yihong, Chen, Jiewei, Liu, Zexian, Zuo, Zhixiang, Pan, Zhizhong, Zhou, Penghui, Zheng, Jian, Ding, Pei-Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009229/ https://www.ncbi.nlm.nih.gov/pubmed/33782107 http://dx.doi.org/10.1136/jitc-2020-001498

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