Long-range PEG stapling: macrocyclization for increased protein conformational stability and resistance to proteolysis

We previously showed that long-range stapling of two Asn-linked O-allyl PEG oligomers via olefin metathesis substantially increases the conformational stability of the WW domain through an entropic effect. The impact of stapling was more favorable when the staple connected positions that were far ap...

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Detalles Bibliográficos
Autores principales: Xiao, Qiang, Ashton, Dallin S., Jones, Zachary B., Thompson, Katherine P., Price, Joshua L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009319/
https://www.ncbi.nlm.nih.gov/pubmed/33796855
http://dx.doi.org/10.1039/d0cb00075b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009319/
https://www.ncbi.nlm.nih.gov/pubmed/33796855
http://dx.doi.org/10.1039/d0cb00075b

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