Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors

The 20S proteasome is a valuable target for the treatment of a number of diseases including cancer, neurodegenerative disease, and parasitic infection. In an effort to discover novel inhibitors of the 20S proteasome, many reseaarchers have looked to natural products as potential leads for drug disco...

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Detalles Bibliográficos
Autores principales: Hubbell, Grace E., Tepe, Jetze J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009326/
https://www.ncbi.nlm.nih.gov/pubmed/33791679
http://dx.doi.org/10.1039/d0cb00111b
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author Hubbell, Grace E.
Tepe, Jetze J.
author_facet Hubbell, Grace E.
Tepe, Jetze J.
author_sort Hubbell, Grace E.
collection PubMed
description The 20S proteasome is a valuable target for the treatment of a number of diseases including cancer, neurodegenerative disease, and parasitic infection. In an effort to discover novel inhibitors of the 20S proteasome, many reseaarchers have looked to natural products as potential leads for drug discovery. The following review discusses the efforts made in the field to isolate and identify natural products as inhibitors of the proteasome. In addition, we describe some of the modifications made to natural products in order to discover more potent and selective inhibitors for potential disease treatment.
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spelling pubmed-80093262021-03-30 Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors Hubbell, Grace E. Tepe, Jetze J. RSC Chem Biol Chemistry The 20S proteasome is a valuable target for the treatment of a number of diseases including cancer, neurodegenerative disease, and parasitic infection. In an effort to discover novel inhibitors of the 20S proteasome, many reseaarchers have looked to natural products as potential leads for drug discovery. The following review discusses the efforts made in the field to isolate and identify natural products as inhibitors of the proteasome. In addition, we describe some of the modifications made to natural products in order to discover more potent and selective inhibitors for potential disease treatment. RSC 2020-09-16 /pmc/articles/PMC8009326/ /pubmed/33791679 http://dx.doi.org/10.1039/d0cb00111b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Hubbell, Grace E.
Tepe, Jetze J.
Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors
title Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors
title_full Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors
title_fullStr Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors
title_full_unstemmed Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors
title_short Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors
title_sort natural product scaffolds as inspiration for the design and synthesis of 20s human proteasome inhibitors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009326/
https://www.ncbi.nlm.nih.gov/pubmed/33791679
http://dx.doi.org/10.1039/d0cb00111b
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