Hydrosulfide-selective ChemFETs for aqueous H(2)S/HS(−) measurement

We have prepared and characterized hydrosulfide-selective ChemFET devices based on a nitrile butadiene rubber membrane containing tetraoctylammonium nitrate as a chemical recognition element that is applied to commercially available field-effect transistors. The sensors have fast (120 s) reversible responses, selectivity over other biologically relevant thiol-containing species, detection limits of 8 mM, and a detection range from approximately 5 to 500 mM. Sensitivities are shown to be 53 mV per decade at pH 8. Use of this compact, benchtop sensor platform requires little training – only the ability to measure DC voltage, which can be accomplished with a conventional multimeter or a simple analog data acquisition device paired with a personal computer. To the best of our knowledge, this report describes the first example of direct potentiometric measurement of the hydrosulfide ion in water.