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Feasibility and reliability of sequential logic with gene regulatory networks
Gene regulatory networks exhibiting Boolean behaviour, e.g. AND, OR or XOR, have been routinely designed for years. However, achieving more sophisticated functions, such as control or computation, usually requires sequential circuits or so-called state machines. For such a circuit, outputs depend bo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009411/ https://www.ncbi.nlm.nih.gov/pubmed/33784367 http://dx.doi.org/10.1371/journal.pone.0249234 |
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author | Madec, Morgan Rosati, Elise Lallement, Christophe |
author_facet | Madec, Morgan Rosati, Elise Lallement, Christophe |
author_sort | Madec, Morgan |
collection | PubMed |
description | Gene regulatory networks exhibiting Boolean behaviour, e.g. AND, OR or XOR, have been routinely designed for years. However, achieving more sophisticated functions, such as control or computation, usually requires sequential circuits or so-called state machines. For such a circuit, outputs depend both on inputs and the current state of the system. Although it is still possible to design such circuits by analogy with digital electronics, some particularities of biology make the task trickier. The impact of two of them, namely the stochasticity of biological processes and the inhomogeneity in the response of regulation mechanisms, are assessed in this paper. Numerical simulations performed in two use cases point out high risks of malfunctions even for designed GRNs functional from a theoretical point of view. Several solutions to improve reliability of such systems are also discussed. |
format | Online Article Text |
id | pubmed-8009411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80094112021-04-07 Feasibility and reliability of sequential logic with gene regulatory networks Madec, Morgan Rosati, Elise Lallement, Christophe PLoS One Research Article Gene regulatory networks exhibiting Boolean behaviour, e.g. AND, OR or XOR, have been routinely designed for years. However, achieving more sophisticated functions, such as control or computation, usually requires sequential circuits or so-called state machines. For such a circuit, outputs depend both on inputs and the current state of the system. Although it is still possible to design such circuits by analogy with digital electronics, some particularities of biology make the task trickier. The impact of two of them, namely the stochasticity of biological processes and the inhomogeneity in the response of regulation mechanisms, are assessed in this paper. Numerical simulations performed in two use cases point out high risks of malfunctions even for designed GRNs functional from a theoretical point of view. Several solutions to improve reliability of such systems are also discussed. Public Library of Science 2021-03-30 /pmc/articles/PMC8009411/ /pubmed/33784367 http://dx.doi.org/10.1371/journal.pone.0249234 Text en © 2021 Madec et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Madec, Morgan Rosati, Elise Lallement, Christophe Feasibility and reliability of sequential logic with gene regulatory networks |
title | Feasibility and reliability of sequential logic with gene regulatory networks |
title_full | Feasibility and reliability of sequential logic with gene regulatory networks |
title_fullStr | Feasibility and reliability of sequential logic with gene regulatory networks |
title_full_unstemmed | Feasibility and reliability of sequential logic with gene regulatory networks |
title_short | Feasibility and reliability of sequential logic with gene regulatory networks |
title_sort | feasibility and reliability of sequential logic with gene regulatory networks |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009411/ https://www.ncbi.nlm.nih.gov/pubmed/33784367 http://dx.doi.org/10.1371/journal.pone.0249234 |
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