Cargando…
Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined t...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009415/ https://www.ncbi.nlm.nih.gov/pubmed/33735294 http://dx.doi.org/10.1371/journal.ppat.1009397 |
_version_ | 1783672871108739072 |
---|---|
author | Bataille, Arnaud Salami, Habib Seck, Ismaila Lo, Modou Moustapha Ba, Aminata Diop, Mariame Sall, Baba Faye, Coumba Lo, Mbargou Kaba, Lanceï Sidime, Youssouf Keyra, Mohamed Diallo, Alpha Oumar Sily Niang, Mamadou Sidibe, Cheick Abou Kounta Sery, Amadou Dakouo, Martin El Mamy, Ahmed Bezeid El Arbi, Ahmed Salem Barry, Yahya Isselmou, Ekaterina Habiboullah, Habiboullah Lella, Abdellahi Salem Doumbia, Baba Gueya, Mohamed Baba Coste, Caroline Squarzoni Diaw, Cécile Kwiatek, Olivier Libeau, Geneviève Apolloni, Andrea |
author_facet | Bataille, Arnaud Salami, Habib Seck, Ismaila Lo, Modou Moustapha Ba, Aminata Diop, Mariame Sall, Baba Faye, Coumba Lo, Mbargou Kaba, Lanceï Sidime, Youssouf Keyra, Mohamed Diallo, Alpha Oumar Sily Niang, Mamadou Sidibe, Cheick Abou Kounta Sery, Amadou Dakouo, Martin El Mamy, Ahmed Bezeid El Arbi, Ahmed Salem Barry, Yahya Isselmou, Ekaterina Habiboullah, Habiboullah Lella, Abdellahi Salem Doumbia, Baba Gueya, Mohamed Baba Coste, Caroline Squarzoni Diaw, Cécile Kwiatek, Olivier Libeau, Geneviève Apolloni, Andrea |
author_sort | Bataille, Arnaud |
collection | PubMed |
description | Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential “hotspots” for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility. |
format | Online Article Text |
id | pubmed-8009415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80094152021-04-07 Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa Bataille, Arnaud Salami, Habib Seck, Ismaila Lo, Modou Moustapha Ba, Aminata Diop, Mariame Sall, Baba Faye, Coumba Lo, Mbargou Kaba, Lanceï Sidime, Youssouf Keyra, Mohamed Diallo, Alpha Oumar Sily Niang, Mamadou Sidibe, Cheick Abou Kounta Sery, Amadou Dakouo, Martin El Mamy, Ahmed Bezeid El Arbi, Ahmed Salem Barry, Yahya Isselmou, Ekaterina Habiboullah, Habiboullah Lella, Abdellahi Salem Doumbia, Baba Gueya, Mohamed Baba Coste, Caroline Squarzoni Diaw, Cécile Kwiatek, Olivier Libeau, Geneviève Apolloni, Andrea PLoS Pathog Research Article Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential “hotspots” for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility. Public Library of Science 2021-03-18 /pmc/articles/PMC8009415/ /pubmed/33735294 http://dx.doi.org/10.1371/journal.ppat.1009397 Text en © 2021 Bataille et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bataille, Arnaud Salami, Habib Seck, Ismaila Lo, Modou Moustapha Ba, Aminata Diop, Mariame Sall, Baba Faye, Coumba Lo, Mbargou Kaba, Lanceï Sidime, Youssouf Keyra, Mohamed Diallo, Alpha Oumar Sily Niang, Mamadou Sidibe, Cheick Abou Kounta Sery, Amadou Dakouo, Martin El Mamy, Ahmed Bezeid El Arbi, Ahmed Salem Barry, Yahya Isselmou, Ekaterina Habiboullah, Habiboullah Lella, Abdellahi Salem Doumbia, Baba Gueya, Mohamed Baba Coste, Caroline Squarzoni Diaw, Cécile Kwiatek, Olivier Libeau, Geneviève Apolloni, Andrea Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa |
title | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa |
title_full | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa |
title_fullStr | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa |
title_full_unstemmed | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa |
title_short | Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa |
title_sort | combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in west africa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009415/ https://www.ncbi.nlm.nih.gov/pubmed/33735294 http://dx.doi.org/10.1371/journal.ppat.1009397 |
work_keys_str_mv | AT bataillearnaud combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT salamihabib combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT seckismaila combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT lomodoumoustapha combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT baaminata combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT diopmariame combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT sallbaba combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT fayecoumba combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT lombargou combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT kabalancei combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT sidimeyoussouf combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT keyramohamed combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT dialloalphaoumarsily combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT niangmamadou combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT sidibecheickaboukounta combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT seryamadou combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT dakouomartin combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT elmamyahmedbezeid combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT elarbiahmedsalem combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT barryyahya combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT isselmouekaterina combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT habiboullahhabiboullah combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT lellaabdellahisalem combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT doumbiababa combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT gueyamohamedbaba combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT costecaroline combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT squarzonidiawcecile combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT kwiatekolivier combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT libeaugenevieve combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica AT apolloniandrea combiningviralgeneticandanimalmobilitynetworkdatatounravelpestedespetitsruminantstransmissiondynamicsinwestafrica |