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Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa

Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined t...

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Autores principales: Bataille, Arnaud, Salami, Habib, Seck, Ismaila, Lo, Modou Moustapha, Ba, Aminata, Diop, Mariame, Sall, Baba, Faye, Coumba, Lo, Mbargou, Kaba, Lanceï, Sidime, Youssouf, Keyra, Mohamed, Diallo, Alpha Oumar Sily, Niang, Mamadou, Sidibe, Cheick Abou Kounta, Sery, Amadou, Dakouo, Martin, El Mamy, Ahmed Bezeid, El Arbi, Ahmed Salem, Barry, Yahya, Isselmou, Ekaterina, Habiboullah, Habiboullah, Lella, Abdellahi Salem, Doumbia, Baba, Gueya, Mohamed Baba, Coste, Caroline, Squarzoni Diaw, Cécile, Kwiatek, Olivier, Libeau, Geneviève, Apolloni, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009415/
https://www.ncbi.nlm.nih.gov/pubmed/33735294
http://dx.doi.org/10.1371/journal.ppat.1009397
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author Bataille, Arnaud
Salami, Habib
Seck, Ismaila
Lo, Modou Moustapha
Ba, Aminata
Diop, Mariame
Sall, Baba
Faye, Coumba
Lo, Mbargou
Kaba, Lanceï
Sidime, Youssouf
Keyra, Mohamed
Diallo, Alpha Oumar Sily
Niang, Mamadou
Sidibe, Cheick Abou Kounta
Sery, Amadou
Dakouo, Martin
El Mamy, Ahmed Bezeid
El Arbi, Ahmed Salem
Barry, Yahya
Isselmou, Ekaterina
Habiboullah, Habiboullah
Lella, Abdellahi Salem
Doumbia, Baba
Gueya, Mohamed Baba
Coste, Caroline
Squarzoni Diaw, Cécile
Kwiatek, Olivier
Libeau, Geneviève
Apolloni, Andrea
author_facet Bataille, Arnaud
Salami, Habib
Seck, Ismaila
Lo, Modou Moustapha
Ba, Aminata
Diop, Mariame
Sall, Baba
Faye, Coumba
Lo, Mbargou
Kaba, Lanceï
Sidime, Youssouf
Keyra, Mohamed
Diallo, Alpha Oumar Sily
Niang, Mamadou
Sidibe, Cheick Abou Kounta
Sery, Amadou
Dakouo, Martin
El Mamy, Ahmed Bezeid
El Arbi, Ahmed Salem
Barry, Yahya
Isselmou, Ekaterina
Habiboullah, Habiboullah
Lella, Abdellahi Salem
Doumbia, Baba
Gueya, Mohamed Baba
Coste, Caroline
Squarzoni Diaw, Cécile
Kwiatek, Olivier
Libeau, Geneviève
Apolloni, Andrea
author_sort Bataille, Arnaud
collection PubMed
description Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential “hotspots” for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility.
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spelling pubmed-80094152021-04-07 Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa Bataille, Arnaud Salami, Habib Seck, Ismaila Lo, Modou Moustapha Ba, Aminata Diop, Mariame Sall, Baba Faye, Coumba Lo, Mbargou Kaba, Lanceï Sidime, Youssouf Keyra, Mohamed Diallo, Alpha Oumar Sily Niang, Mamadou Sidibe, Cheick Abou Kounta Sery, Amadou Dakouo, Martin El Mamy, Ahmed Bezeid El Arbi, Ahmed Salem Barry, Yahya Isselmou, Ekaterina Habiboullah, Habiboullah Lella, Abdellahi Salem Doumbia, Baba Gueya, Mohamed Baba Coste, Caroline Squarzoni Diaw, Cécile Kwiatek, Olivier Libeau, Geneviève Apolloni, Andrea PLoS Pathog Research Article Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential “hotspots” for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility. Public Library of Science 2021-03-18 /pmc/articles/PMC8009415/ /pubmed/33735294 http://dx.doi.org/10.1371/journal.ppat.1009397 Text en © 2021 Bataille et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bataille, Arnaud
Salami, Habib
Seck, Ismaila
Lo, Modou Moustapha
Ba, Aminata
Diop, Mariame
Sall, Baba
Faye, Coumba
Lo, Mbargou
Kaba, Lanceï
Sidime, Youssouf
Keyra, Mohamed
Diallo, Alpha Oumar Sily
Niang, Mamadou
Sidibe, Cheick Abou Kounta
Sery, Amadou
Dakouo, Martin
El Mamy, Ahmed Bezeid
El Arbi, Ahmed Salem
Barry, Yahya
Isselmou, Ekaterina
Habiboullah, Habiboullah
Lella, Abdellahi Salem
Doumbia, Baba
Gueya, Mohamed Baba
Coste, Caroline
Squarzoni Diaw, Cécile
Kwiatek, Olivier
Libeau, Geneviève
Apolloni, Andrea
Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
title Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
title_full Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
title_fullStr Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
title_full_unstemmed Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
title_short Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
title_sort combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in west africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009415/
https://www.ncbi.nlm.nih.gov/pubmed/33735294
http://dx.doi.org/10.1371/journal.ppat.1009397
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