Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction

Synthetic lethality is a successful strategy employed to develop selective chemotherapeutics against cancer cells. Inactivation of RAD52 is synthetically lethal to homologous recombination (HR) deficient cancer cell lines. Replication protein A (RPA) recruits RAD52 to repair sites, and the formation...

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Detalles Bibliográficos
Autores principales: Al-Mugotir, Mona, Lovelace, Jeffrey J., George, Joseph, Bessho, Mika, Pal, Dhananjaya, Struble, Lucas, Kolar, Carol, Rana, Sandeep, Natarajan, Amarnath, Bessho, Tadayoshi, Borgstahl, Gloria E. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009417/
https://www.ncbi.nlm.nih.gov/pubmed/33784323
http://dx.doi.org/10.1371/journal.pone.0248941

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