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High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California

Trans women have been understudied in the Hepatitis C virus (HCV) epidemic, yet data suggest they may be at elevated risk of the disease. Using data collected from the Centers for Disease Control and Prevention’s (CDC) National HIV Behavioral Surveillance (NHBS) survey, we measured HCV seropositivit...

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Autores principales: Hernandez, Christopher J., Trujillo, Dillon, Sicro, Sofia, Meza, Joaquin, Bella, Mackie, Daza, Emperatriz, Torres, Francisco, McFarland, Willi, Turner, Caitlin M., Wilson, Erin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009419/
https://www.ncbi.nlm.nih.gov/pubmed/33784365
http://dx.doi.org/10.1371/journal.pone.0249219
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author Hernandez, Christopher J.
Trujillo, Dillon
Sicro, Sofia
Meza, Joaquin
Bella, Mackie
Daza, Emperatriz
Torres, Francisco
McFarland, Willi
Turner, Caitlin M.
Wilson, Erin C.
author_facet Hernandez, Christopher J.
Trujillo, Dillon
Sicro, Sofia
Meza, Joaquin
Bella, Mackie
Daza, Emperatriz
Torres, Francisco
McFarland, Willi
Turner, Caitlin M.
Wilson, Erin C.
author_sort Hernandez, Christopher J.
collection PubMed
description Trans women have been understudied in the Hepatitis C virus (HCV) epidemic, yet data suggest they may be at elevated risk of the disease. Using data collected from the Centers for Disease Control and Prevention’s (CDC) National HIV Behavioral Surveillance (NHBS) survey, we measured HCV seropositivity, viremia, and associated risk factors for HCV infection among trans women in San Francisco from June 2019 to February 2020. Respondent-driven sampling (RDS) was used to obtain a diverse, community-based sample of 201 trans women, of whom 48 (23.9%, 95% CI 17.9% - 30.0%) were HCV seropositive. HCV seropositivity significantly increased with increasing age (adjusted prevalence ratio [APR] 1.04 per year, 95% CI 1.01–1.07) and history of injection drug use (APR 4.44, 95% CI 2.15–9.18). We also found that many had HCV viremia as twelve (6.0% of the total sample, 95% CI 2.7% - 9.3%) were RNA-positive for HCV. Trans women are highly impacted by HCV and could benefit from access to regular and frequent HCV screening and treatment access. HCV screening could be offered regularly in trans-specific health services, in the community, in jails and prisons, and integrated syringe exchange programs where treatment access or referral are also available.
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spelling pubmed-80094192021-04-07 High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California Hernandez, Christopher J. Trujillo, Dillon Sicro, Sofia Meza, Joaquin Bella, Mackie Daza, Emperatriz Torres, Francisco McFarland, Willi Turner, Caitlin M. Wilson, Erin C. PLoS One Research Article Trans women have been understudied in the Hepatitis C virus (HCV) epidemic, yet data suggest they may be at elevated risk of the disease. Using data collected from the Centers for Disease Control and Prevention’s (CDC) National HIV Behavioral Surveillance (NHBS) survey, we measured HCV seropositivity, viremia, and associated risk factors for HCV infection among trans women in San Francisco from June 2019 to February 2020. Respondent-driven sampling (RDS) was used to obtain a diverse, community-based sample of 201 trans women, of whom 48 (23.9%, 95% CI 17.9% - 30.0%) were HCV seropositive. HCV seropositivity significantly increased with increasing age (adjusted prevalence ratio [APR] 1.04 per year, 95% CI 1.01–1.07) and history of injection drug use (APR 4.44, 95% CI 2.15–9.18). We also found that many had HCV viremia as twelve (6.0% of the total sample, 95% CI 2.7% - 9.3%) were RNA-positive for HCV. Trans women are highly impacted by HCV and could benefit from access to regular and frequent HCV screening and treatment access. HCV screening could be offered regularly in trans-specific health services, in the community, in jails and prisons, and integrated syringe exchange programs where treatment access or referral are also available. Public Library of Science 2021-03-30 /pmc/articles/PMC8009419/ /pubmed/33784365 http://dx.doi.org/10.1371/journal.pone.0249219 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Hernandez, Christopher J.
Trujillo, Dillon
Sicro, Sofia
Meza, Joaquin
Bella, Mackie
Daza, Emperatriz
Torres, Francisco
McFarland, Willi
Turner, Caitlin M.
Wilson, Erin C.
High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California
title High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California
title_full High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California
title_fullStr High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California
title_full_unstemmed High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California
title_short High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California
title_sort high hepatitis c virus seropositivity, viremia, and associated risk factors among trans women living in san francisco, california
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009419/
https://www.ncbi.nlm.nih.gov/pubmed/33784365
http://dx.doi.org/10.1371/journal.pone.0249219
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