Adenovirus-vectored T cell vaccine for hepacivirus shows reduced effectiveness against a CD8 T cell escape variant in rats

There is an urgent need for a vaccine to prevent chronic infection by hepatitis C virus (HCV) and its many genetic variants. The first human vaccine trial, using recombinant viral vectors that stimulate pan-genotypic T cell responses against HCV non-structural proteins, failed to demonstrate efficac...

Descripción completa

Detalles Bibliográficos
Autores principales: Hartlage, Alex S., Dravid, Piyush, Walker, Christopher M., Kapoor, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009437/
https://www.ncbi.nlm.nih.gov/pubmed/33735321
http://dx.doi.org/10.1371/journal.ppat.1009391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009437/
https://www.ncbi.nlm.nih.gov/pubmed/33735321
http://dx.doi.org/10.1371/journal.ppat.1009391

Ejemplares similares