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A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors

INTRODUCTION: Angiotensin-converting enzyme 2 (ACE2) is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effects of SARS-CoV-2 on normal pituitary glands function or pituitary neuroendocrine tumors (PitNETs) have not yet been elucidated. Thus, the present study aimed...

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Autores principales: Gu, Wei Ting, Zhou, Fen, Xie, Wan Qun, Wang, Shuo, Yao, Hong, Liu, Yan Ting, Gao, Ling, Wu, Zhe Bao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009460/
https://www.ncbi.nlm.nih.gov/pubmed/33786714
http://dx.doi.org/10.1007/s12020-021-02697-y
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author Gu, Wei Ting
Zhou, Fen
Xie, Wan Qun
Wang, Shuo
Yao, Hong
Liu, Yan Ting
Gao, Ling
Wu, Zhe Bao
author_facet Gu, Wei Ting
Zhou, Fen
Xie, Wan Qun
Wang, Shuo
Yao, Hong
Liu, Yan Ting
Gao, Ling
Wu, Zhe Bao
author_sort Gu, Wei Ting
collection PubMed
description INTRODUCTION: Angiotensin-converting enzyme 2 (ACE2) is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effects of SARS-CoV-2 on normal pituitary glands function or pituitary neuroendocrine tumors (PitNETs) have not yet been elucidated. Thus, the present study aimed to investigate the potential risks of SARS-CoV-2 infection on the impairment of pituitary glands and the development of PitNETs. METHODS: PitNETs tissues were obtained from 114 patients, and normal pituitary gland tissues were obtained from the autopsy. The mRNA levels of ACE2 and angiotensin II receptor type 1 (AGTR1) were examined by quantitative real-time PCR. Immunohistochemical staining was performed for ACE2 in 69 PitNETs and 3 normal pituitary glands. The primary tumor cells and pituitary cell lines (MMQ, GH3 and AtT-20/D16v-F2) were treated with diminazene aceturate (DIZE), an ACE2 agonist, with various dose regimens. The pituitary hormones between 43 patients with SARS-CoV-2 infection were compared with 45 healthy controls. RESULTS: Pituitary glands and the majority of PitNET tissues showed low/negative ACE2 expression at both the mRNA and protein levels, while AGTR1 showed high expression in normal pituitary and corticotroph adenomas. ACE2 agonist increased the secretion of ACTH in AtT-20/D16v-F2 cells through downregulating AGTR1. The level of serum adrenocorticotropic hormone (ACTH) was significantly increased in COVID-19 patients compared to normal controls (p < 0.001), but was dramatically decreased in critical cases compared to non-critical patients (p = 0.003). CONCLUSIONS: This study revealed a potential impact of SARS-CoV-2 infection on corticotroph cells and adenomas.
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spelling pubmed-80094602021-03-31 A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors Gu, Wei Ting Zhou, Fen Xie, Wan Qun Wang, Shuo Yao, Hong Liu, Yan Ting Gao, Ling Wu, Zhe Bao Endocrine Original Article INTRODUCTION: Angiotensin-converting enzyme 2 (ACE2) is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effects of SARS-CoV-2 on normal pituitary glands function or pituitary neuroendocrine tumors (PitNETs) have not yet been elucidated. Thus, the present study aimed to investigate the potential risks of SARS-CoV-2 infection on the impairment of pituitary glands and the development of PitNETs. METHODS: PitNETs tissues were obtained from 114 patients, and normal pituitary gland tissues were obtained from the autopsy. The mRNA levels of ACE2 and angiotensin II receptor type 1 (AGTR1) were examined by quantitative real-time PCR. Immunohistochemical staining was performed for ACE2 in 69 PitNETs and 3 normal pituitary glands. The primary tumor cells and pituitary cell lines (MMQ, GH3 and AtT-20/D16v-F2) were treated with diminazene aceturate (DIZE), an ACE2 agonist, with various dose regimens. The pituitary hormones between 43 patients with SARS-CoV-2 infection were compared with 45 healthy controls. RESULTS: Pituitary glands and the majority of PitNET tissues showed low/negative ACE2 expression at both the mRNA and protein levels, while AGTR1 showed high expression in normal pituitary and corticotroph adenomas. ACE2 agonist increased the secretion of ACTH in AtT-20/D16v-F2 cells through downregulating AGTR1. The level of serum adrenocorticotropic hormone (ACTH) was significantly increased in COVID-19 patients compared to normal controls (p < 0.001), but was dramatically decreased in critical cases compared to non-critical patients (p = 0.003). CONCLUSIONS: This study revealed a potential impact of SARS-CoV-2 infection on corticotroph cells and adenomas. Springer US 2021-03-30 2021 /pmc/articles/PMC8009460/ /pubmed/33786714 http://dx.doi.org/10.1007/s12020-021-02697-y Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Gu, Wei Ting
Zhou, Fen
Xie, Wan Qun
Wang, Shuo
Yao, Hong
Liu, Yan Ting
Gao, Ling
Wu, Zhe Bao
A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors
title A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors
title_full A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors
title_fullStr A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors
title_full_unstemmed A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors
title_short A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors
title_sort potential impact of sars-cov-2 on pituitary glands and pituitary neuroendocrine tumors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009460/
https://www.ncbi.nlm.nih.gov/pubmed/33786714
http://dx.doi.org/10.1007/s12020-021-02697-y
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