Exploration of TRPM8 Binding Sites by β-Carboline-Based Antagonists and Their In Vitro Characterization and In Vivo Analgesic Activities

[Image: see text] Transient receptor potential melastatin 8 (TRPM8) ion channel represents a valuable pharmacological option for several therapeutic areas. Here, a series of conformationally restricted derivatives of the previously described TRPM8 antagonist N,N′-dibenzyl tryptophan 4 were prepared...

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Detalles Bibliográficos
Autores principales: Bertamino, Alessia, Ostacolo, Carmine, Medina, Alicia, Di Sarno, Veronica, Lauro, Gianluigi, Ciaglia, Tania, Vestuto, Vincenzo, Pepe, Giacomo, Basilicata, Manuela Giovanna, Musella, Simona, Smaldone, Gerardina, Cristiano, Claudia, Gonzalez-Rodriguez, Sara, Fernandez-Carvajal, Asia, Bifulco, Giuseppe, Campiglia, Pietro, Gomez-Monterrey, Isabel, Russo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009520/
https://www.ncbi.nlm.nih.gov/pubmed/32787109
http://dx.doi.org/10.1021/acs.jmedchem.0c00816

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