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Lignin: Drug/Gene Delivery and Tissue Engineering Applications

Lignin is an abundant renewable natural biopolymer. Moreover, a significant development in lignin pretreatment and processing technologies has opened a new window to explore lignin and lignin-based bionanomaterials. In the last decade, lignin has been widely explored in different applications such a...

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Autores principales: Kumar, Raj, Butreddy, Arun, Kommineni, Nagavendra, Reddy, Pulikanti Guruprasad, Bunekar, Naveen, Sarkar, Chandrani, Dutt, Sunil, Mishra, Vivek K, Aadil, Keshaw Ram, Mishra, Yogendra Kumar, Oupicky, David, Kaushik, Ajeet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009556/
https://www.ncbi.nlm.nih.gov/pubmed/33814908
http://dx.doi.org/10.2147/IJN.S303462
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author Kumar, Raj
Butreddy, Arun
Kommineni, Nagavendra
Reddy, Pulikanti Guruprasad
Bunekar, Naveen
Sarkar, Chandrani
Dutt, Sunil
Mishra, Vivek K
Aadil, Keshaw Ram
Mishra, Yogendra Kumar
Oupicky, David
Kaushik, Ajeet
author_facet Kumar, Raj
Butreddy, Arun
Kommineni, Nagavendra
Reddy, Pulikanti Guruprasad
Bunekar, Naveen
Sarkar, Chandrani
Dutt, Sunil
Mishra, Vivek K
Aadil, Keshaw Ram
Mishra, Yogendra Kumar
Oupicky, David
Kaushik, Ajeet
author_sort Kumar, Raj
collection PubMed
description Lignin is an abundant renewable natural biopolymer. Moreover, a significant development in lignin pretreatment and processing technologies has opened a new window to explore lignin and lignin-based bionanomaterials. In the last decade, lignin has been widely explored in different applications such as drug and gene delivery, tissue engineering, food science, water purification, biofuels, environmental, pharmaceuticals, nutraceutical, catalysis, and other interesting low-value-added energy applications. The complex nature and antioxidant, antimicrobial, and biocompatibility of lignin attracted its use in various biomedical applications because of ease of functionalization, availability of diverse functional sites, tunable physicochemical and mechanical properties. In addition to it, its diverse properties such as reactivity towards oxygen radical, metal chelation, renewable nature, biodegradability, favorable interaction with cells, nature to mimic the extracellular environment, and ease of nanoparticles preparation make it a very interesting material for biomedical use. Tremendous progress has been made in drug delivery and tissue engineering in recent years. However, still, it remains challenging to identify an ideal and compatible nanomaterial for biomedical applications. In this review, recent progress of lignin towards biomedical applications especially in drug delivery and in tissue engineering along with challenges, future possibilities have been comprehensively reviewed.
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spelling pubmed-80095562021-04-01 Lignin: Drug/Gene Delivery and Tissue Engineering Applications Kumar, Raj Butreddy, Arun Kommineni, Nagavendra Reddy, Pulikanti Guruprasad Bunekar, Naveen Sarkar, Chandrani Dutt, Sunil Mishra, Vivek K Aadil, Keshaw Ram Mishra, Yogendra Kumar Oupicky, David Kaushik, Ajeet Int J Nanomedicine Review Lignin is an abundant renewable natural biopolymer. Moreover, a significant development in lignin pretreatment and processing technologies has opened a new window to explore lignin and lignin-based bionanomaterials. In the last decade, lignin has been widely explored in different applications such as drug and gene delivery, tissue engineering, food science, water purification, biofuels, environmental, pharmaceuticals, nutraceutical, catalysis, and other interesting low-value-added energy applications. The complex nature and antioxidant, antimicrobial, and biocompatibility of lignin attracted its use in various biomedical applications because of ease of functionalization, availability of diverse functional sites, tunable physicochemical and mechanical properties. In addition to it, its diverse properties such as reactivity towards oxygen radical, metal chelation, renewable nature, biodegradability, favorable interaction with cells, nature to mimic the extracellular environment, and ease of nanoparticles preparation make it a very interesting material for biomedical use. Tremendous progress has been made in drug delivery and tissue engineering in recent years. However, still, it remains challenging to identify an ideal and compatible nanomaterial for biomedical applications. In this review, recent progress of lignin towards biomedical applications especially in drug delivery and in tissue engineering along with challenges, future possibilities have been comprehensively reviewed. Dove 2021-03-26 /pmc/articles/PMC8009556/ /pubmed/33814908 http://dx.doi.org/10.2147/IJN.S303462 Text en © 2021 Kumar et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Kumar, Raj
Butreddy, Arun
Kommineni, Nagavendra
Reddy, Pulikanti Guruprasad
Bunekar, Naveen
Sarkar, Chandrani
Dutt, Sunil
Mishra, Vivek K
Aadil, Keshaw Ram
Mishra, Yogendra Kumar
Oupicky, David
Kaushik, Ajeet
Lignin: Drug/Gene Delivery and Tissue Engineering Applications
title Lignin: Drug/Gene Delivery and Tissue Engineering Applications
title_full Lignin: Drug/Gene Delivery and Tissue Engineering Applications
title_fullStr Lignin: Drug/Gene Delivery and Tissue Engineering Applications
title_full_unstemmed Lignin: Drug/Gene Delivery and Tissue Engineering Applications
title_short Lignin: Drug/Gene Delivery and Tissue Engineering Applications
title_sort lignin: drug/gene delivery and tissue engineering applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009556/
https://www.ncbi.nlm.nih.gov/pubmed/33814908
http://dx.doi.org/10.2147/IJN.S303462
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