Cargando…

Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance

[Image: see text] The expression of multidrug resistance P-glycoprotein (P-gp) by cancer cells represents one of the major drawbacks to successful cancer therapy. Accordingly, the development of drugs that inhibit the activity of this transporter remains a major challenge in cancer drug discovery. I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bortolozzi, Roberta, Luraghi, Andrea, Mattiuzzo, Elena, Sacchetti, Alessandro, Silvani, Alessandra, Viola, Giampietro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society and American Society of Pharmacognosy 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009596/ https://www.ncbi.nlm.nih.gov/pubmed/32790992 http://dx.doi.org/10.1021/acs.jnatprod.0c00334

Ejemplares similares

Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives
por: Lesma, Giordano, et al.
Publicado: (2014)

Ecdysteroid 7,9(11)-dien-6-ones as potential photoaffinity labels for ecdysteroid binding proteins
por: Bourne, Pauline C., et al.
Publicado: (2002)

A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents
por: Bortolozzi, Roberta, et al.
Publicado: (2014)

Reversal Effect of Oxypeucedanin on P-glycoprotein-mediated Drug Transport
por: Dong, Wei, et al.
Publicado: (2018)

Novel Ecdysteroids from Serratula wolffii
por: Ványolós, Attila, et al.
Publicado: (2012)

Ecdysteroids: production in plant in vitro cultures
por: Thiem, Barbara, et al.
Publicado: (2016)

Ecdysteroids: A novel class of anabolic agents?
por: Parr, MK, et al.
Publicado: (2015)

Ecdysteroids are present in the blood of wild passerine birds
por: Hornok, Sándor, et al.
Publicado: (2019)

Histone Deacetylase Inhibitors Impair Glioblastoma Cell Motility and Proliferation
por: Rampazzo, Elena, et al.
Publicado: (2022)

Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction
por: Cosimelli, Barbara, et al.
Publicado: (2019)

Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein
por: Sajid, Andaleeb, et al.
Publicado: (2020)

The expression of ecdysteroid UDP-glucosyltransferase enhances cocoon shell ratio by reducing ecdysteroid titre in last-instar larvae of silkworm, Bombyx mori
por: Shen, Guanwang, et al.
Publicado: (2018)

Diversity-Oriented Synthesis Catalyzed by Diethylaminosulfur-Trifluoride—Preparation of New Antitumor Ecdysteroid Derivatives
por: Vágvölgyi, Máté, et al.
Publicado: (2022)

Ecdysteroids, Juvenile Hormone and Vitellogenesis in the Cockroach Leucophaea maderae.
por: Engelmann, Franz
Publicado: (2002)

Practical uses for ecdysteroids in mammals including humans: an update
por: Lafont, R., et al.
Publicado: (2003)

Ecdysteroids and oocyte development in the black fly Simulium vittatum
por: Noriega, Rafael, et al.
Publicado: (2002)

Ecdysteroid Content and Therapeutic Activity in Elicited Spinach Accessions
por: Gorelick, Jonathan, et al.
Publicado: (2020)

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure
por: Airaghi, Francesco, et al.
Publicado: (2013)

Tissue Damage Disrupts Developmental Progression and Ecdysteroid Biosynthesis in Drosophila
por: Hackney, Jennifer F., et al.
Publicado: (2012)

Transcriptional Regulators of Ecdysteroid Biosynthetic Enzymes and Their Roles in Insect Development
por: Kamiyama, Takumi, et al.
Publicado: (2022)

Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative.
por: Dale, I. L., et al.
Publicado: (1998)

The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation
por: Porcù, Elena, et al.
Publicado: (2016)

Transporter-mediated ecdysteroid trafficking across cell membranes: A novel target for insect growth regulators
por: Okamoto, Naoki, et al.
Publicado: (2021)

Lycorine Carbamate Derivatives for Reversing P-glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells
por: Sancha, Shirley A. R., et al.
Publicado: (2023)

UVB Radiation Delays Tribolium castaneum Metamorphosis by Influencing Ecdysteroid Metabolism
por: Sang, Wen, et al.
Publicado: (2016)

Ecdysonelactones, Ecdysteroids from the Tropical Eastern Pacific Zoantharian Antipathozoanthus hickmani
por: Guillen, Paul O., et al.
Publicado: (2018)

Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum
por: Hansen, Kine Østnes, et al.
Publicado: (2018)

Toxic Relationships: Prediction of TBT’s Affinity to the Ecdysteroid Receptor of Triops longicaudatus
por: Ferreira, Nuno Gonçalo de Carvalho, et al.
Publicado: (2023)

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa
por: Ausserlechner, Michael J., et al.
Publicado: (2013)

Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative
por: González, María L., et al.
Publicado: (2017)

Bromocriptine Reverses P‐Glycoprotein‐mediated Multidrug Resistance in Tumor Cells
por: Shiraki, Nobuaki, et al.
Publicado: (2002)

P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors
por: Kopecka, Joanna, et al.
Publicado: (2016)

EcR/USP-1-mediated ecdysteroid signaling regulates wolf spider (Pardosa pseudoannulata) development and reproduction
por: Yang, Zhi-Ming, et al.
Publicado: (2023)

DNA self-assembly nanoflower reverse P-glycoprotein mediated drug resistance in chronic myelogenous leukemia therapy
por: Zhao, Pengxuan, et al.
Publicado: (2023)

Synthesis and Structure-Activity Relationships of Novel Ecdysteroid Dioxolanes as MDR Modulators in Cancer
por: Martins, Ana, et al.
Publicado: (2013)

The ecdysteroid receptor regulates salivary gland degeneration through apoptosis in Rhipicephalus haemaphysaloides
por: Lu, Xiaojuan, et al.
Publicado: (2021)

SoxC is Required for Ecdysteroid Induction of Neuropeptide Genes During Insect Eclosion
por: Luo, Guang-Hua, et al.
Publicado: (2022)

Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold
por: Romagnoli, Romeo, et al.
Publicado: (2023)

Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma
por: Mariotto, Elena, et al.
Publicado: (2023)

Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance
por: Quan, Xingping, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lbbrko3q0rnt2r8de3sgthn11r