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Deaminated purine bypass by DNA polymerase η
A recent work by Jung and colleagues (Biochem J. 477, 4797–4810) provides an explanation of how DNA polymerase η replicates through deaminated purine bases such as xanthine and hypoxanthine. This commentary discusses the crystal structures of the polymerase η complexes that implicate the role of tau...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009656/ https://www.ncbi.nlm.nih.gov/pubmed/33779688 http://dx.doi.org/10.1042/BCJ20200989 |
| Sumario: | A recent work by Jung and colleagues (Biochem J. 477, 4797–4810) provides an explanation of how DNA polymerase η replicates through deaminated purine bases such as xanthine and hypoxanthine. This commentary discusses the crystal structures of the polymerase η complexes that implicate the role of tautomerism in the bypass of these DNA lesions. |
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