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Deaminated purine bypass by DNA polymerase η
A recent work by Jung and colleagues (Biochem J. 477, 4797–4810) provides an explanation of how DNA polymerase η replicates through deaminated purine bases such as xanthine and hypoxanthine. This commentary discusses the crystal structures of the polymerase η complexes that implicate the role of tau...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009656/ https://www.ncbi.nlm.nih.gov/pubmed/33779688 http://dx.doi.org/10.1042/BCJ20200989 |
| _version_ | 1783672919290806272 |
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| author | Andreeva, Antonina |
| author_facet | Andreeva, Antonina |
| author_sort | Andreeva, Antonina |
| collection | PubMed |
| description | A recent work by Jung and colleagues (Biochem J. 477, 4797–4810) provides an explanation of how DNA polymerase η replicates through deaminated purine bases such as xanthine and hypoxanthine. This commentary discusses the crystal structures of the polymerase η complexes that implicate the role of tautomerism in the bypass of these DNA lesions. |
| format | Online Article Text |
| id | pubmed-8009656 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Portland Press Ltd. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-80096562021-04-08 Deaminated purine bypass by DNA polymerase η Andreeva, Antonina Biochem J Structural Biology A recent work by Jung and colleagues (Biochem J. 477, 4797–4810) provides an explanation of how DNA polymerase η replicates through deaminated purine bases such as xanthine and hypoxanthine. This commentary discusses the crystal structures of the polymerase η complexes that implicate the role of tautomerism in the bypass of these DNA lesions. Portland Press Ltd. 2021-04-16 2021-03-29 /pmc/articles/PMC8009656/ /pubmed/33779688 http://dx.doi.org/10.1042/BCJ20200989 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Structural Biology Andreeva, Antonina Deaminated purine bypass by DNA polymerase η |
| title | Deaminated purine bypass by DNA polymerase η |
| title_full | Deaminated purine bypass by DNA polymerase η |
| title_fullStr | Deaminated purine bypass by DNA polymerase η |
| title_full_unstemmed | Deaminated purine bypass by DNA polymerase η |
| title_short | Deaminated purine bypass by DNA polymerase η |
| title_sort | deaminated purine bypass by dna polymerase η |
| topic | Structural Biology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009656/ https://www.ncbi.nlm.nih.gov/pubmed/33779688 http://dx.doi.org/10.1042/BCJ20200989 |
| work_keys_str_mv | AT andreevaantonina deaminatedpurinebypassbydnapolymeraseē |