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Group phenotypic composition in cancer

Although individual cancer cells are generally considered the Darwinian units of selection in malignant populations, they frequently act as members of groups where fitness of the group cannot be reduced to the average fitness of individual group members. A growing body of studies reveals limitations...

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Autores principales: Capp, Jean-Pascal, DeGregori, James, Nedelcu, Aurora M, Dujon, Antoine M, Boutry, Justine, Pujol, Pascal, Alix-Panabières, Catherine, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata, Marusyk, Andriy, Gatenby, Robert, Thomas, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009660/
https://www.ncbi.nlm.nih.gov/pubmed/33784238
http://dx.doi.org/10.7554/eLife.63518
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author Capp, Jean-Pascal
DeGregori, James
Nedelcu, Aurora M
Dujon, Antoine M
Boutry, Justine
Pujol, Pascal
Alix-Panabières, Catherine
Hamede, Rodrigo
Roche, Benjamin
Ujvari, Beata
Marusyk, Andriy
Gatenby, Robert
Thomas, Frédéric
author_facet Capp, Jean-Pascal
DeGregori, James
Nedelcu, Aurora M
Dujon, Antoine M
Boutry, Justine
Pujol, Pascal
Alix-Panabières, Catherine
Hamede, Rodrigo
Roche, Benjamin
Ujvari, Beata
Marusyk, Andriy
Gatenby, Robert
Thomas, Frédéric
author_sort Capp, Jean-Pascal
collection PubMed
description Although individual cancer cells are generally considered the Darwinian units of selection in malignant populations, they frequently act as members of groups where fitness of the group cannot be reduced to the average fitness of individual group members. A growing body of studies reveals limitations of reductionist approaches to explaining biological and clinical observations. For example, induction of angiogenesis, inhibition of the immune system, and niche engineering through environmental acidification and/or remodeling of extracellular matrix cannot be achieved by single tumor cells and require collective actions of groups of cells. Success or failure of such group activities depends on the phenotypic makeup of the individual group members. Conversely, these group activities affect the fitness of individual members of the group, ultimately affecting the composition of the group. This phenomenon, where phenotypic makeup of individual group members impacts the fitness of both members and groups, has been captured in the term ‘group phenotypic composition’ (GPC). We provide examples where considerations of GPC could help in understanding the evolution and clinical progression of cancers and argue that use of the GPC framework can facilitate new insights into cancer biology and assist with the development of new therapeutic strategies.
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spelling pubmed-80096602021-03-31 Group phenotypic composition in cancer Capp, Jean-Pascal DeGregori, James Nedelcu, Aurora M Dujon, Antoine M Boutry, Justine Pujol, Pascal Alix-Panabières, Catherine Hamede, Rodrigo Roche, Benjamin Ujvari, Beata Marusyk, Andriy Gatenby, Robert Thomas, Frédéric eLife Evolutionary Biology Although individual cancer cells are generally considered the Darwinian units of selection in malignant populations, they frequently act as members of groups where fitness of the group cannot be reduced to the average fitness of individual group members. A growing body of studies reveals limitations of reductionist approaches to explaining biological and clinical observations. For example, induction of angiogenesis, inhibition of the immune system, and niche engineering through environmental acidification and/or remodeling of extracellular matrix cannot be achieved by single tumor cells and require collective actions of groups of cells. Success or failure of such group activities depends on the phenotypic makeup of the individual group members. Conversely, these group activities affect the fitness of individual members of the group, ultimately affecting the composition of the group. This phenomenon, where phenotypic makeup of individual group members impacts the fitness of both members and groups, has been captured in the term ‘group phenotypic composition’ (GPC). We provide examples where considerations of GPC could help in understanding the evolution and clinical progression of cancers and argue that use of the GPC framework can facilitate new insights into cancer biology and assist with the development of new therapeutic strategies. eLife Sciences Publications, Ltd 2021-03-30 /pmc/articles/PMC8009660/ /pubmed/33784238 http://dx.doi.org/10.7554/eLife.63518 Text en © 2021, Capp et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Capp, Jean-Pascal
DeGregori, James
Nedelcu, Aurora M
Dujon, Antoine M
Boutry, Justine
Pujol, Pascal
Alix-Panabières, Catherine
Hamede, Rodrigo
Roche, Benjamin
Ujvari, Beata
Marusyk, Andriy
Gatenby, Robert
Thomas, Frédéric
Group phenotypic composition in cancer
title Group phenotypic composition in cancer
title_full Group phenotypic composition in cancer
title_fullStr Group phenotypic composition in cancer
title_full_unstemmed Group phenotypic composition in cancer
title_short Group phenotypic composition in cancer
title_sort group phenotypic composition in cancer
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009660/
https://www.ncbi.nlm.nih.gov/pubmed/33784238
http://dx.doi.org/10.7554/eLife.63518
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