Bevacizumab-Induced Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and ERK Inactivation Contribute to Cardiotoxicity

The molecular mechanisms underlying the cardiotoxicity associated with bevacizumab, a first-line immunotherapeutic agent used to treat lung cancer, are not fully understood. Here, we examined intracellular signal transduction in cardiomyocytes after exposure to different doses of bevacizumab in vitr...

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Detalles Bibliográficos
Autores principales: Li, Yue, Tian, Wei, Yue, Dongsheng, Chen, Chen, Li, Chenguang, Zhang, Zhenfa, Wang, Changli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009725/
https://www.ncbi.nlm.nih.gov/pubmed/33859777
http://dx.doi.org/10.1155/2021/5548130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009725/
https://www.ncbi.nlm.nih.gov/pubmed/33859777
http://dx.doi.org/10.1155/2021/5548130

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