The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance

The complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer development and metastasis. As the primary regulator of the process, epithelial-mesenchymal transition-regulating transcription factors (EMT-TFs) play key role...

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Autores principales: Seo, Jihye, Ha, Jain, Kang, Eunjeong, Cho, Sayeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pharmaceutical Society of Korea 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009775/
https://www.ncbi.nlm.nih.gov/pubmed/33768509
http://dx.doi.org/10.1007/s12272-021-01321-x
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author Seo, Jihye
Ha, Jain
Kang, Eunjeong
Cho, Sayeon
author_facet Seo, Jihye
Ha, Jain
Kang, Eunjeong
Cho, Sayeon
author_sort Seo, Jihye
collection PubMed
description The complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer development and metastasis. As the primary regulator of the process, epithelial-mesenchymal transition-regulating transcription factors (EMT-TFs) play key roles in metastasis. They are also highlighted in recent preclinical studies on resistance to cancer therapy. This review describes the role of three main EMT-TFs, including Snail, Twist1, and zinc-finger E homeobox-binding 1 (ZEB1), relating to drug resistance and current possible approaches for future challenges targeting EMT-TFs.
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spelling pubmed-80097752021-04-16 The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance Seo, Jihye Ha, Jain Kang, Eunjeong Cho, Sayeon Arch Pharm Res Review The complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer development and metastasis. As the primary regulator of the process, epithelial-mesenchymal transition-regulating transcription factors (EMT-TFs) play key roles in metastasis. They are also highlighted in recent preclinical studies on resistance to cancer therapy. This review describes the role of three main EMT-TFs, including Snail, Twist1, and zinc-finger E homeobox-binding 1 (ZEB1), relating to drug resistance and current possible approaches for future challenges targeting EMT-TFs. Pharmaceutical Society of Korea 2021-03-25 2021 /pmc/articles/PMC8009775/ /pubmed/33768509 http://dx.doi.org/10.1007/s12272-021-01321-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Seo, Jihye
Ha, Jain
Kang, Eunjeong
Cho, Sayeon
The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
title The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
title_full The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
title_fullStr The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
title_full_unstemmed The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
title_short The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
title_sort role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009775/
https://www.ncbi.nlm.nih.gov/pubmed/33768509
http://dx.doi.org/10.1007/s12272-021-01321-x
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