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EQ-5D-Y Value Set for Slovenia

BACKGROUND: A value set for the EuroQoL 5-Dimensions (EQ-5D)-Y in Slovenia is not yet available, making the calculation of quality-adjusted life-years (QALYs) for children and adolescents using this generic instrument impossible. OBJECTIVE: The main objective of our study was to obtain adult prefere...

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Detalles Bibliográficos
Autores principales: Prevolnik Rupel, Valentina, Ogorevc, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009800/
https://www.ncbi.nlm.nih.gov/pubmed/33565048
http://dx.doi.org/10.1007/s40273-020-00994-4
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author Prevolnik Rupel, Valentina
Ogorevc, Marko
author_facet Prevolnik Rupel, Valentina
Ogorevc, Marko
author_sort Prevolnik Rupel, Valentina
collection PubMed
description BACKGROUND: A value set for the EuroQoL 5-Dimensions (EQ-5D)-Y in Slovenia is not yet available, making the calculation of quality-adjusted life-years (QALYs) for children and adolescents using this generic instrument impossible. OBJECTIVE: The main objective of our study was to obtain adult preferences towards EQ-5D-Y health states in Slovenia, following the EQ-5D-Y-3L international valuation protocol. The adults were asked to take the perspective of a hypothetical 10-year-old child. METHOD: A sample of 1074 adults in Slovenia completed an online discrete-choice experiment (DCE) survey on EQ-5D-Y health states. The latent scale issue was addressed by obtaining the value of the anchor (33333) with 200 composite time trade-off (cTTO) interviews. A mixed (random coefficients) logit model was used to estimate the value set. RESULTS: All the estimated coefficients of the mixed logit model were statistically significant at the 1% level and had an expected negative sign. The most important health dimension in EQ-5D-Y is pain/discomfort, followed by anxiety/depression, usual activities, and mobility, with self-care being the least important health dimension. CONCLUSIONS: The study addresses an important research gap and presents the EQ-5D-Y value set for Slovenia. At the time of writing, no published value sets are available for the EQ-5D-Y-3L appropriate for use in QALY calculations, making this value set the first EQ-5D-Y value set in the world. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40273-020-00994-4.
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spelling pubmed-80098002021-04-16 EQ-5D-Y Value Set for Slovenia Prevolnik Rupel, Valentina Ogorevc, Marko Pharmacoeconomics Original Research Article BACKGROUND: A value set for the EuroQoL 5-Dimensions (EQ-5D)-Y in Slovenia is not yet available, making the calculation of quality-adjusted life-years (QALYs) for children and adolescents using this generic instrument impossible. OBJECTIVE: The main objective of our study was to obtain adult preferences towards EQ-5D-Y health states in Slovenia, following the EQ-5D-Y-3L international valuation protocol. The adults were asked to take the perspective of a hypothetical 10-year-old child. METHOD: A sample of 1074 adults in Slovenia completed an online discrete-choice experiment (DCE) survey on EQ-5D-Y health states. The latent scale issue was addressed by obtaining the value of the anchor (33333) with 200 composite time trade-off (cTTO) interviews. A mixed (random coefficients) logit model was used to estimate the value set. RESULTS: All the estimated coefficients of the mixed logit model were statistically significant at the 1% level and had an expected negative sign. The most important health dimension in EQ-5D-Y is pain/discomfort, followed by anxiety/depression, usual activities, and mobility, with self-care being the least important health dimension. CONCLUSIONS: The study addresses an important research gap and presents the EQ-5D-Y value set for Slovenia. At the time of writing, no published value sets are available for the EQ-5D-Y-3L appropriate for use in QALY calculations, making this value set the first EQ-5D-Y value set in the world. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40273-020-00994-4. Springer International Publishing 2021-02-10 2021 /pmc/articles/PMC8009800/ /pubmed/33565048 http://dx.doi.org/10.1007/s40273-020-00994-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Original Research Article
Prevolnik Rupel, Valentina
Ogorevc, Marko
EQ-5D-Y Value Set for Slovenia
title EQ-5D-Y Value Set for Slovenia
title_full EQ-5D-Y Value Set for Slovenia
title_fullStr EQ-5D-Y Value Set for Slovenia
title_full_unstemmed EQ-5D-Y Value Set for Slovenia
title_short EQ-5D-Y Value Set for Slovenia
title_sort eq-5d-y value set for slovenia
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009800/
https://www.ncbi.nlm.nih.gov/pubmed/33565048
http://dx.doi.org/10.1007/s40273-020-00994-4
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