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1/f-noise-free optical sensing with an integrated heterodyne interferometer
Optical evanescent sensors can non-invasively detect unlabeled nanoscale objects in real time with unprecedented sensitivity, enabling a variety of advances in fundamental physics and biological applications. However, the intrinsic low-frequency noise therein with an approximately 1/f-shaped spectra...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009908/ https://www.ncbi.nlm.nih.gov/pubmed/33785760 http://dx.doi.org/10.1038/s41467-021-22271-4 |
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author | Jin, Ming Tang, Shui-Jing Chen, Jin-Hui Yu, Xiao-Chong Shu, Haowen Tao, Yuansheng Chen, Antony K. Gong, Qihuang Wang, Xingjun Xiao, Yun-Feng |
author_facet | Jin, Ming Tang, Shui-Jing Chen, Jin-Hui Yu, Xiao-Chong Shu, Haowen Tao, Yuansheng Chen, Antony K. Gong, Qihuang Wang, Xingjun Xiao, Yun-Feng |
author_sort | Jin, Ming |
collection | PubMed |
description | Optical evanescent sensors can non-invasively detect unlabeled nanoscale objects in real time with unprecedented sensitivity, enabling a variety of advances in fundamental physics and biological applications. However, the intrinsic low-frequency noise therein with an approximately 1/f-shaped spectral density imposes an ultimate detection limit for monitoring many paramount processes, such as antigen-antibody reactions, cell motions and DNA hybridizations. Here, we propose and demonstrate a 1/f-noise-free optical sensor through an up-converted detection system. Experimentally, in a CMOS-compatible heterodyne interferometer, the sampling noise amplitude is suppressed by two orders of magnitude. It pushes the label-free single-nanoparticle detection limit down to the attogram level without exploiting cavity resonances, plasmonic effects, or surface charges on the analytes. Single polystyrene nanobeads and HIV-1 virus-like particles are detected as a proof-of-concept demonstration for airborne biosensing. Based on integrated waveguide arrays, our devices hold great potentials for multiplexed and rapid sensing of diverse viruses or molecules. |
format | Online Article Text |
id | pubmed-8009908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80099082021-04-16 1/f-noise-free optical sensing with an integrated heterodyne interferometer Jin, Ming Tang, Shui-Jing Chen, Jin-Hui Yu, Xiao-Chong Shu, Haowen Tao, Yuansheng Chen, Antony K. Gong, Qihuang Wang, Xingjun Xiao, Yun-Feng Nat Commun Article Optical evanescent sensors can non-invasively detect unlabeled nanoscale objects in real time with unprecedented sensitivity, enabling a variety of advances in fundamental physics and biological applications. However, the intrinsic low-frequency noise therein with an approximately 1/f-shaped spectral density imposes an ultimate detection limit for monitoring many paramount processes, such as antigen-antibody reactions, cell motions and DNA hybridizations. Here, we propose and demonstrate a 1/f-noise-free optical sensor through an up-converted detection system. Experimentally, in a CMOS-compatible heterodyne interferometer, the sampling noise amplitude is suppressed by two orders of magnitude. It pushes the label-free single-nanoparticle detection limit down to the attogram level without exploiting cavity resonances, plasmonic effects, or surface charges on the analytes. Single polystyrene nanobeads and HIV-1 virus-like particles are detected as a proof-of-concept demonstration for airborne biosensing. Based on integrated waveguide arrays, our devices hold great potentials for multiplexed and rapid sensing of diverse viruses or molecules. Nature Publishing Group UK 2021-03-30 /pmc/articles/PMC8009908/ /pubmed/33785760 http://dx.doi.org/10.1038/s41467-021-22271-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jin, Ming Tang, Shui-Jing Chen, Jin-Hui Yu, Xiao-Chong Shu, Haowen Tao, Yuansheng Chen, Antony K. Gong, Qihuang Wang, Xingjun Xiao, Yun-Feng 1/f-noise-free optical sensing with an integrated heterodyne interferometer |
title | 1/f-noise-free optical sensing with an integrated heterodyne interferometer |
title_full | 1/f-noise-free optical sensing with an integrated heterodyne interferometer |
title_fullStr | 1/f-noise-free optical sensing with an integrated heterodyne interferometer |
title_full_unstemmed | 1/f-noise-free optical sensing with an integrated heterodyne interferometer |
title_short | 1/f-noise-free optical sensing with an integrated heterodyne interferometer |
title_sort | 1/f-noise-free optical sensing with an integrated heterodyne interferometer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009908/ https://www.ncbi.nlm.nih.gov/pubmed/33785760 http://dx.doi.org/10.1038/s41467-021-22271-4 |
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