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Sensors for the detection of ammonia as a potential biomarker for health screening
The presence of ammonia within the body has long been linked to complications stemming from the liver, kidneys, and stomach. These complications can be the result of serious conditions such as chronic kidney disease (CKD), peptic ulcers, and recently COVID-19. Limited liver and kidney function leads...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009942/ https://www.ncbi.nlm.nih.gov/pubmed/33785837 http://dx.doi.org/10.1038/s41598-021-86686-1 |
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author | Ricci, Peter P. Gregory, Otto J. |
author_facet | Ricci, Peter P. Gregory, Otto J. |
author_sort | Ricci, Peter P. |
collection | PubMed |
description | The presence of ammonia within the body has long been linked to complications stemming from the liver, kidneys, and stomach. These complications can be the result of serious conditions such as chronic kidney disease (CKD), peptic ulcers, and recently COVID-19. Limited liver and kidney function leads to increased blood urea nitrogen (BUN) within the body resulting in elevated levels of ammonia in the mouth, nose, and skin. Similarly, peptic ulcers, commonly from H. pylori, result in ammonia production from urea within the stomach. The presence of these biomarkers enables a potential screening protocol to be considered for frequent, non-invasive monitoring of these conditions. Unfortunately, detection of ammonia in these mediums is rather challenging due to relatively small concentrations and an abundance of interferents. Currently, there are no options available for non-invasive screening of these conditions continuously and in real-time. Here we demonstrate the selective detection of ammonia using a vapor phase thermodynamic sensing platform capable of being employed as part of a health screening protocol. The results show that our detection system has the remarkable ability to selectively detect trace levels of ammonia in the vapor phase using a single catalyst. Additionally, detection was demonstrated in the presence of interferents such as carbon dioxide (CO(2)) and acetone common in human breath. These results show that our thermodynamic sensors are well suited to selectively detect ammonia at levels that could potentially be useful for health screening applications. |
format | Online Article Text |
id | pubmed-8009942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80099422021-04-01 Sensors for the detection of ammonia as a potential biomarker for health screening Ricci, Peter P. Gregory, Otto J. Sci Rep Article The presence of ammonia within the body has long been linked to complications stemming from the liver, kidneys, and stomach. These complications can be the result of serious conditions such as chronic kidney disease (CKD), peptic ulcers, and recently COVID-19. Limited liver and kidney function leads to increased blood urea nitrogen (BUN) within the body resulting in elevated levels of ammonia in the mouth, nose, and skin. Similarly, peptic ulcers, commonly from H. pylori, result in ammonia production from urea within the stomach. The presence of these biomarkers enables a potential screening protocol to be considered for frequent, non-invasive monitoring of these conditions. Unfortunately, detection of ammonia in these mediums is rather challenging due to relatively small concentrations and an abundance of interferents. Currently, there are no options available for non-invasive screening of these conditions continuously and in real-time. Here we demonstrate the selective detection of ammonia using a vapor phase thermodynamic sensing platform capable of being employed as part of a health screening protocol. The results show that our detection system has the remarkable ability to selectively detect trace levels of ammonia in the vapor phase using a single catalyst. Additionally, detection was demonstrated in the presence of interferents such as carbon dioxide (CO(2)) and acetone common in human breath. These results show that our thermodynamic sensors are well suited to selectively detect ammonia at levels that could potentially be useful for health screening applications. Nature Publishing Group UK 2021-03-30 /pmc/articles/PMC8009942/ /pubmed/33785837 http://dx.doi.org/10.1038/s41598-021-86686-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ricci, Peter P. Gregory, Otto J. Sensors for the detection of ammonia as a potential biomarker for health screening |
title | Sensors for the detection of ammonia as a potential biomarker for health screening |
title_full | Sensors for the detection of ammonia as a potential biomarker for health screening |
title_fullStr | Sensors for the detection of ammonia as a potential biomarker for health screening |
title_full_unstemmed | Sensors for the detection of ammonia as a potential biomarker for health screening |
title_short | Sensors for the detection of ammonia as a potential biomarker for health screening |
title_sort | sensors for the detection of ammonia as a potential biomarker for health screening |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009942/ https://www.ncbi.nlm.nih.gov/pubmed/33785837 http://dx.doi.org/10.1038/s41598-021-86686-1 |
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