SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study the dynamics of adaptive immune response in COVID-19 patients requiring intensive care. Before seroconversion in respons...

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Autores principales: Ferreira-Gomes, Marta, Kruglov, Andrey, Durek, Pawel, Heinrich, Frederik, Tizian, Caroline, Heinz, Gitta Anne, Pascual-Reguant, Anna, Du, Weijie, Mothes, Ronja, Fan, Chaofan, Frischbutter, Stefan, Habenicht, Katharina, Budzinski, Lisa, Ninnemann, Justus, Jani, Peter K., Guerra, Gabriela Maria, Lehmann, Katrin, Matz, Mareen, Ostendorf, Lennard, Heiberger, Lukas, Chang, Hyun-Dong, Bauherr, Sandy, Maurer, Marcus, Schönrich, Günther, Raftery, Martin, Kallinich, Tilmann, Mall, Marcus Alexander, Angermair, Stefan, Treskatsch, Sascha, Dörner, Thomas, Corman, Victor Max, Diefenbach, Andreas, Volk, Hans-Dieter, Elezkurtaj, Sefer, Winkler, Thomas H., Dong, Jun, Hauser, Anja Erika, Radbruch, Helena, Witkowski, Mario, Melchers, Fritz, Radbruch, Andreas, Mashreghi, Mir-Farzin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010106/
https://www.ncbi.nlm.nih.gov/pubmed/33785765
http://dx.doi.org/10.1038/s41467-021-22210-3

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